ArticleInvestigative and clinical urology2025
Low minimal alveolar concentration general anesthesia for pain control in percutaneous radiofrequency ablation: Influence on long-term outcomes of renal cell carcinoma.
Article in Investigative and clinical urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe study aims to retrospectively examine performance of general anesthesia in percutaneous radiofrequency ablation (RFA) of renal cell carcinoma (RCC) and to assess the long-term outcomes. MATERIALS AND
methodsBetween September 2012 and August 2019, 87 patients (68 males and 19 females; mean age, 61 years) with biopsy-proven T1a RCC underwent computed tomography-guided RFA under general anesthesia. Anesthetic time, minimal alveolar concentration (MAC), and post-anesthetic complications were recorded. Primary effectiveness and local tumor progression (LTP)-free and metastasis-free survival rates were calculated. Major complications following RFA were assessed. A Kaplan-Meier analysis was used to determine the long-term survival rate.
resultsGeneral anesthesia and RFA were performed with 100% technical success. The mean time of general anesthesia was 127 minutes (range, 63-248 minutes). The mean MAC was 0.88±0.15. There was no complication related to general anesthesia. Primary effectiveness was 100%, and the 5-year LTP-free or metastasis-free rate was 97.7% (85/87). One major RFA complication occurred in a patient with ureter stricture that was detected during a follow-up examination.
conclusionsLow-MAC general anesthesia during RFA procedures is appropriate for precise RCC targeting. This type of pain control could influence the long-term outcomes of RCC patients.
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