Evidence map›Paper›PMID 41184111›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025

[Cytotoxic effects of the novel photosensitizer PEG

Lingjuan Chen, Qi Wang, Lu Wang, Yifei Shen, Haibin Wang, Hengxin Wang, Xuejie Su, Meixu Lei, Xianxia Chen, Chengjin Ai and 2 more

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Protective effects of SESN2 on Erastin-induced ferroptosis in renal tubular cells and acute kidney injury].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lingjuan ChenDepartment of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072. cljkeyan@sina.com.
Qi WangCuiying Biomedical Research Center, Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030.
Lu WangDepartment of Nuclear Medicine, Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030.
Yifei ShenCuiying Biomedical Research Center, Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030.
Haibin WangCuiying Biomedical Research Center, Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030.
Hengxin WangCuiying Biomedical Research Center, Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030.
Xuejie SuCuiying Biomedical Research Center, Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030.
Meixu LeiCuiying Biomedical Research Center, Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030.
Xianxia ChenDepartment of Dermatology, Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, China.
Chengjin AiDepartment of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072.
Yifan LiDepartment of Dermatology, Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030, China.
Yali ZhouCuiying Biomedical Research Center, Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030. zhouyali1956@163.com.

Funding

the Cuiying Scientific Training Program for Undergraduates of the Second Hospital & Clinical Medical School, Lanzhou University China. CYXZ2022-08
6 · The paper itself

Abstract

objectivesThe application of photodynamic therapy in solid tumors has attracted increasing attention in recent years, and the efficiency of photosensitizers is a crucial determinant of therapeutic efficacy. This study aims to evaluate the cytotoxic effects of a novel photosensitizer, PEG-MTPABZ-PyC, in photodynamic therapy against gastric cancer cells.

methodsGastric cancer MKN45 cells were treated with PEG-MTPABZ-PyC. A high-content live-cell imaging system was used to assess the cellular uptake kinetics and subcellular localization of the photosensitizer. The cytotoxic effects of PEG-MTPABZ-PyC-mediated photodynamic therapy were examined using the cell counting kit-8 (CCK-8) assay and flow cytometry, while the intrinsic cytotoxicity of the photosensitizer alone was verified by the CCK-8 assay. Intracellular reactive oxygen species (ROS) generation after photodynamic therapy was detected using 2'-7'-dichlorodihydrofluorescein diacetate (DCFH-DA).

resultsPEG-MTPABZ-PyC alone exhibited no cytotoxicity toward MKN45 cells, indicating excellent cytocompatibility. The compound efficiently entered cells within 6 hours and localized predominantly in lysosomes. Upon light irradiation, PEG-MTPABZ-PyC-mediated photodynamic therapy induced significant cytotoxicity compared with the control group (

conclusionsThe novel photosensitizer PEG-MTPABZ-PyC demonstrates potent photodynamic cytotoxicity against gastric cancer cells, showing promising potential for further development in gastric cancer photodynamic therapy.

Indexed as

MesoporphyrinsPhotochemotherapyPhotosensitizing AgentsPolyethylene GlycolsStomach NeoplasmsCell Line, TumorHumansReactive Oxygen SpeciesMesoporphyrinsPhotosensitizing AgentsPolyethylene GlycolsReactive Oxygen Speciescytotoxic effectgastric cancernovel photosensitizerPEG-MTPABZ-PyCphotodynamic therapy

Identifiers

PMID41184111
PMCPMC12554869

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.