Evidence map›Paper›PMID 41184110›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2025

[Effect of astragaloside IV on osteogenic differentiation of BMSCs in osteoporotic rats via regulation of miR-21 and inhibition of the Notch signaling pathway].

Jingjing Xiao, Xiaolan Liu, Jianying Huang, Ben Dou

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jingjing XiaoFirst Department of Orthopedics and Traumatology, Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410008, China. 17673631326@163.com.
Xiaolan LiuFirst Department of Orthopedics and Traumatology, Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410008, China.
Jianying HuangFirst Department of Orthopedics and Traumatology, Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410008, China.
Ben DouFirst Department of Orthopedics and Traumatology, Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410008, China. 20301256@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe core pathology of osteoporosis lies in bone resorption exceeding bone formation; thus, promoting osteogenesis is a key therapeutic strategy. The osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) forms the biological basis of bone formation. Astragaloside IV (A-IV), a major active component of Astragalus membranaceus, is known to enhance osteogenesis, but its precise molecular mechanisms remain unclear. This study aims to investigate the effects of A-IV on the proliferation and osteogenic differentiation of BMSCs from osteoporotic rats and to elucidate its molecular mechanism through the regulation of microRNA-21 (miR-21) and Notch2 expression.

methodsAfter 1 week of adaptive feeding, mature female SD rats were randomly divided into a sham-operated (Sham) group (

resultsFlow cytometry confirmed that O-BMSCs retained the phenotypic characteristics of mesenchymal stem cells. A-IV significantly enhanced the proliferation of BMSCs from osteoporotic rats (

conclusionsAstragaloside IV promotes the osteogenic differentiation of BMSCs derived from osteoporotic rats by upregulating miR-21 expression and inhibiting the key Notch signaling protein Notch2, thereby relieving the Notch2-mediated suppression of osteogenesis.

Indexed as

Cell DifferentiationMesenchymal Stem CellsMicroRNAsOsteogenesisOsteoporosisReceptor, Notch2SaponinsTriterpenesAnimalsCell ProliferationCells, CulturedFemaleOvariectomyRatsRats, Sprague-DawleyReceptors, Notchastragaloside AMicroRNAsmirn21 microRNA, ratNotch2 protein, ratReceptor, Notch2Receptors, NotchSaponinsTriterpenesastragaloside IVbone marrow mesenchymal stem cellsNotch signaling pathwayosteogenic differentiationosteoporosis

Identifiers

PMID41184110
PMCPMC12554865

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.