ArticleJournal of digestive diseases
The Association Between Accelerated Biological Aging as Measured by KDMAge and PhenoAge and Digestive System Cancer Risk: A Cross-Sectional Study Using NHANES Data (1999-2018).
Article in Journal of digestive diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The mediating role of biological age acceleration in the associations between lifestyle factors and incident digestive system cancers: A Prospective Cohort Study from the UK Biobank.The journal of nutrition, health & aging · 2026Article
- The Association Between Accelerated Biological Aging as Measured by KDMAge and PhenoAge and Digestive System Cancer Risk: A Cross-Sectional Study Using NHANES Data (1999-2018).Journal of digestive diseasesArticle
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9 authors.
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Abstract
objectivesDigestive system cancer (DSC) continues to pose a significant global health challenge, and cost-effective biomarkers for its early detection remain scarce. We aimed to evaluate the potential of two biological aging indicators, namely the Klemera-Doubal method age (KDMAge) and the phenotypic age (PhenoAge), for predicting DSC risk.
methodsUsing the National Health and Nutrition Examination Survey (NHANES) dataset (1999-2018), biological age acceleration for KDMAge and PhenoAge was calculated as residuals from linear regression models of each biological age on chronological age. Accelerated aging was defined as positive residuals. Their associations with DSC risk were evaluated using weighted logistic regression and restricted cubic spline (RCS) analysis. Predictive performance was assessed via area under the receiver operating characteristic curve (AUROC), and robustness was examined using propensity score matching (PSM) analysis.
resultsA significant positive linear association was observed between KDMAge acceleration and DSC risk (odds ratio 1.59, 95% confidence interval 1.05-2.39, p = 0.027). While PhenoAge acceleration showed a U-shaped nonlinear relationship (p = 0.0197), with minimal risk at -2.95. Both indices showed moderate predictive accuracy (AUROC: KDMAge 0.683 and PhenoAge 0.682). PSM analysis confirmed the robustness of the nonlinear relationship between PhenoAge acceleration and DSC, although the linear trend of KDMAge was attenuated after matching.
conclusionThere was a significant association between accelerated biological aging, as assessed by KDMAge acceleration and PhenoAge acceleration, and DSC risk. Given the cross-sectional study design, causal inference is precluded; however, both indices may be used to develop novel risk assessment tools and guide future research on interventional strategies.
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