Evidence map›Paper›PMID 41183986›Full record

SynthesisJournal of digestive diseases

Prevalence of Celiac Disease in China Among High-Risk Populations: A Systematic Review and Meta-Analysis.

Ying Lian Xiao, Ya Qi Jia, Li Qun Gu, Min Hu Chen

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Journal of digestive diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ying Lian XiaoDepartment of Gastroenterology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China.
Ya Qi JiaMedical Affairs, Takeda (China) Holdings Co., Ltd, Beijing, China.ORCID https://orcid.org/0000-0002-1738-5475
Li Qun GuTakeda Development Center Asia, Shanghai, China.
Min Hu ChenDepartment of Gastroenterology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China.ORCID https://orcid.org/0000-0003-2421-9966

Funding

Takeda (China) Holdings Co., Ltd.
6 · The paper itself

Abstract

objectiveWe conducted this systematic review and meta-analysis to summarize the prevalence of celiac disease (CeD) among high-risk populations in China.

methodsA systematic search was conducted in PubMed, EMBASE, Cochrane Library, Web of Science, and four Chinese databases to identify studies published up to December 10, 2024 on the prevalence of CeD in different regions of China. The high-risk populations included patients with irritable bowel syndrome, gastrointestinal symptoms, autoimmune disease, low body mass index, short stature, etc. Data were extracted from the included studies by two reviewers independently using a standardized data extraction form. Regional prevalence estimates were weighted using China Population Census Yearbook 2020 data. The pooled prevalence of CeD was summarized using random-effects models.

resultsTwenty-eight studies involving 9531 individuals were included. Biopsy-confirmed prevalence and seroprevalence varied widely by region. Central China had the highest biopsy-confirmed prevalence of CeD in high-risk populations (4.55%, 95% confidence interval [CI] 0.66%-8.44%), followed by North China (3.60%, 95% CI 1.75%-6.08%) and East China (2.50%, 95% CI 1.39%-3.94%). Northeast China led in seroprevalence (7.10%, 95% CI 1.14%-13.05%), followed by Central China (4.42%, 95% CI 1.04%-9.98%), East China (4.37%, 95% CI 2.12%-7.38%), and North China (4.35%, 95% CI 2.39%-6.86%). The biopsy-confirmed prevalence and seroprevalence of CeD among high-risk populations in China were 3.69% and 4.43%, respectively.

conclusionCeD prevalence appears to be significant among high-risk populations and varies by geographical regions in China.

Indexed as

Celiac DiseaseChinaHumansPrevalenceRisk Factorsceliac diseaseChinairritable bowel syndromeprevalencetype 1 diabetes mellitus

Identifiers

PMID41183986
PMCPMC12681390

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.