Evidence map›Paper›PMID 41183666›Full record

ReviewVirus research2025

Antineoplastic agents-associated hepatitis B virus reactivation: Research progress and molecular mechanisms.

Huajie Xie, Meijun Lv, Qin Jia, Yanyan Wang, Wanlin Na, Yuan Liu, Kai Chang

Abstract readReview
In one paragraph

Review in Virus research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. SEOM-GGCC clinical guidelines for the prophylaxis of infectious diseases in patients with cancer (UPDATE 2026).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huajie XieDepartment of Laboratory Medicine, The General Hospital of Western Theater Command, Chengdu, Sichuan Province, PR China.
Meijun LvDepartment of Laboratory Medicine, The General Hospital of Western Theater Command, Chengdu, Sichuan Province, PR China.
Qin JiaDepartment of Laboratory Medicine, The General Hospital of Western Theater Command, Chengdu, Sichuan Province, PR China.
Yanyan WangDepartment of Laboratory Medicine, The General Hospital of Western Theater Command, Chengdu, Sichuan Province, PR China.
Wanlin NaDepartment of Laboratory Medicine, The General Hospital of Western Theater Command, Chengdu, Sichuan Province, PR China.
Yuan LiuDepartment of Laboratory Medicine, The General Hospital of Western Theater Command, Chengdu, Sichuan Province, PR China.
Kai ChangDepartment of Laboratory Medicine, The General Hospital of Western Theater Command, Chengdu, Sichuan Province, PR China. Electronic address: ck8148@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HBV infection is a major global health concern, leading to numerous HBV-related deaths. Due to the lack of curative or eradicative treatments for HBV, a large number of individuals in the general population are at risk of HBV reactivation. The increasing application of ICIs for treating various malignancies has raised concerns about HBV reactivation caused by these therapies. HBV reactivation complicates the treatments, leading to the interruption or modification of therapeutic regimens, which presents a considerable challenge. In this review, we summarize relevant researches on the definition, prevalence, and pathogenesis of HBV reactivation. Furthermore, we discuss the risks and mechanism of HBV reactivation during ICIs treatment, outline management strategies for HBV reactivation, and provide recommendations for assessing and monitoring HBV status during the treatment process.

Indexed as

Antineoplastic AgentsHepatitis BHepatitis B virusVirus ActivationAntiviral AgentsHumansAntineoplastic AgentsAntiviral AgentsCTLA-4HBV reactivationICIsPD-1PD-L1

Identifiers

PMID41183666
PMCPMC12630044

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.