Evidence map›Paper›PMID 41183286›Full record

ArticleChemMedChem2025

Dual Biological Potential: Anticancer and Antibacterial Activities of Bis-α, ω-Bifunctional Sphingolipids from the Marine Sponge Oceanapia ramsayi.

Dele Abdissa Keneni, Idris Njanje, Jarmo-Charles Julian Kalinski, Michelle Isaacs, Tarryn Swart, Candace Davison, Jo-Anne de la Mare, Rosemary Ann Dorrington

Abstract read
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In one paragraph

Article in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dele Abdissa KeneniDepartment of Chemistry, Rhodes University, Makhanda, 6140, South Africa.ORCID https://orcid.org/0000-0002-7610-4178
Idris NjanjeDepartment of Biochemistry, Microbiology and Bioinformatics, Rhodes University, Makhanda, 6140, South Africa.ORCID https://orcid.org/0000-0002-8754-4566
Jarmo-Charles Julian KalinskiDepartment of Biochemistry, Microbiology and Bioinformatics, Rhodes University, Makhanda, 6140, South Africa.ORCID https://orcid.org/0000-0001-9641-2912
Michelle IsaacsDepartment of Biochemistry, Microbiology and Bioinformatics, Rhodes University, Makhanda, 6140, South Africa.ORCID https://orcid.org/0000-0002-0694-7487
Tarryn SwartDepartment of Biochemistry, Microbiology and Bioinformatics, Rhodes University, Makhanda, 6140, South Africa.ORCID https://orcid.org/0000-0002-8519-681X
Candace DavisonDepartment of Biochemistry, Microbiology and Bioinformatics, Rhodes University, Makhanda, 6140, South Africa.ORCID https://orcid.org/0000-0002-8288-9290
Jo-Anne de la MareDepartment of Biochemistry, Microbiology and Bioinformatics, Rhodes University, Makhanda, 6140, South Africa.
Rosemary Ann DorringtonDepartment of Biochemistry, Microbiology and Bioinformatics, Rhodes University, Makhanda, 6140, South Africa.ORCID https://orcid.org/0000-0002-8694-367X

Funding

Deutscher Akademischer Austauschdienst France 91758998German Academic Exchange Service 91700877NRF African Coelacanth Ecosystem Programme GUN: 97967South African Medical Research Council AMR DD96815South African National Research Foundation GUN: 87583
6 · The paper itself

Abstract

Marine sponges of the genus Oceanapia are prolific producers of bioactive secondary metabolites. Four known bifunctional sphingolipids are isolated: isorhizochalin (1), rhizochalin (2), rhizochalin C (3), and oceanapiside (4) from Oceanapia ramsayi sponges. These compounds are derivatized to form aglycones (1b-4b), perbenzoates (1c-4c), and bis-oxazoline (2e). The compounds and their derivatives are investigated for their cytotoxicity against three breast cancer cell lines (HCC70, MDA-MB-231, MCF7). All four sphingolipids are cytotoxic with significant selectivity indices (SI) for the three breast cancer cells. Compound 1 has high selectivity against the HCC70 cell line, 4 against the MDA-MB-231 cells, and aglycon 4b against both the MDA-MB-231 and MCF7 cell lines, respectively, demonstrating the functional importance of the sugar units and terminal amino-alcohol stereochemistry. Compounds 1-4 also show promising antibacterial activity against Staphylococcus aureus, Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli, and the multiple antibiotic-resistant Klebsiella pneumoniae test strains, with compound 2 exhibiting the greatest activity. Derivatization diminished potency, indicating that the sugar moiety and stereochemistry are functionally important for antibacterial activity.

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsPoriferaSphingolipidsAnimalsCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsAntineoplastic AgentsSphingolipidsbreast cancerESKAPE pathogensisorhizochalinoceanapisiderhizochalinrhizochalin C

Identifiers

PMID41183286
PMCPMC12640659

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.