Evidence map›Paper›PMID 41183196›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Peptide vaccine formulations with structurally distinct STING agonist drugamers induce discrete, efficacious antitumor responses.

Kefan Song, Dinh Chuong Nguyen, Yonghui Wang, Simbarashe Jokonya, Omeed Yazdani, Drew L Sellers, Patrick S Stayton, Suzie H Pun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kefan Song *Department of Bioengineering, University of Washington, Seattle, WA 98195.ORCID 0000-0002-8925-0094
Dinh Chuong Nguyen *Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195.ORCID 0009-0007-0417-3063
Yonghui WangDepartment of Bioengineering, University of Washington, Seattle, WA 98195.
Simbarashe JokonyaDepartment of Bioengineering, University of Washington, Seattle, WA 98195.ORCID 0000-0002-8199-3598
Omeed YazdaniDepartment of Bioengineering, University of Washington, Seattle, WA 98195.
Drew L SellersDepartment of Bioengineering, University of Washington, Seattle, WA 98195.ORCID 0000-0003-1799-5908
Patrick S StaytonDepartment of Bioengineering, University of Washington, Seattle, WA 98195.
Suzie H PunDepartment of Bioengineering, University of Washington, Seattle, WA 98195.ORCID 0000-0003-1443-4996

Funding

Engineered Antimicrobial Platform to Target Pulmonary Intracellular InfectionsR01AI134729 · NIAID · UNIVERSITY OF WASHINGTON · PI Shawn J. Skerrett, Patrick S. Stayton · 2018 to 2026
$4.9M
An integrated polymeric carrier for subunit cancer vaccinesR01CA257563 · NCI · UNIVERSITY OF WASHINGTON · PI PUN, SUZIE H., STAYTON, PATRICK S. · 2021 to 2025
$2.4M
500 MHz NMR Spectrometer Upgrade and CryoprobeS10OD030224 · OD · UNIVERSITY OF WASHINGTON · PI BREEN, NICHOLAS FRASER · 2022 to 2022
$600k
HHS | NIH | National Cancer Institute (NCI) R01CA257563HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI134729NCI NIH HHS R01 CA257563NIAID NIH HHS R01 AI134729NIH HHS S10 OD030224
6 · The paper itself

Abstract

Peptide therapeutic cancer vaccines are an attractive treatment modality for their safety and manufacturability but have been hindered in clinical translation by low immunogenicity and insufficient CD8

Indexed as

Cancer VaccinesMembrane ProteinsVaccines, SubunitAnimalsCD8-Positive T-LymphocytesCell Line, TumorDendritic CellsFemaleHumansMelanoma, ExperimentalMiceMice, Inbred C57BLNanoparticlesProtein Subunit VaccinesSTING ProteinCancer VaccinesMembrane ProteinsProtein Subunit VaccinesSting1 protein, mouseSTING ProteinVaccines, Subunitcancer immunotherapycancer peptide vaccinepolymeric deliverySTING agonists

Identifiers

PMID41183196
PMCPMC12626017

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.