Evidence map›Paper›PMID 41183185›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Scaffold vaccination for prevention of orthopedic device infection.

Alexander M Tatara, Shanda Lightbown, Shawn Kang, Wei-Hung Jung, Hamza Ijaz, Jean C Lee, Sandra B Nelson, Michael Super, David J Mooney

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Antibiotic-Releasing Porous Shell Cements.Antibiotics (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexander M TataraDepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114.
Shanda LightbownHarvard University Wyss Institute for Biologically Inspired Engineering, Boston, MA 02215.
Shawn KangHarvard University School of Engineering and Applied Sciences, Cambridge, MA 02138.
Wei-Hung JungHarvard University School of Engineering and Applied Sciences, Cambridge, MA 02138.ORCID 0000-0003-4342-4105
Hamza IjazHarvard University Wyss Institute for Biologically Inspired Engineering, Boston, MA 02215.
Jean C LeeBrigham and Women's Hospital, Department of Medicine, Division of Infectious Diseases, Boston, MA 02115.ORCID 0000-0002-8094-5180
Sandra B NelsonDepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0002-1949-7884
Michael SuperHarvard University Wyss Institute for Biologically Inspired Engineering, Boston, MA 02215.ORCID 0000-0002-7410-537X
David J MooneyHarvard University School of Engineering and Applied Sciences, Cambridge, MA 02138.ORCID 0000-0001-6299-1194

Funding

Harvard Clinical and Translational Science CenterUM1TR004408 · NCATS · HARVARD MEDICAL SCHOOL · PI Lindsey Robert Baden, Lee Marshall Nadler · 2023 to 2026
$43.3M
INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1M
Biomaterials-based Immunoengineering for Periprosthetic Joint InfectionK08AI180362 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Alexander Mitchell Tatara · 2024 to 2026
$586k
Characterizing the effects of extracellular matrix viscoelasticity on dendritic cell activationK00CA253759 · NCI · HARVARD UNIVERSITY · PI JUNG, WEI-HUNG · 2022 to 2025
$363k
HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UM1TR004408NCATS NIH HHS UM1 TR004408NCI NIH HHS K00 CA253759NIAID NIH HHS K08 AI180362NIAID NIH HHS T32 AI007061
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Prosthesis-Related InfectionsStaphylococcal InfectionsStaphylococcal VaccinesVaccinationAnimalsDisease Models, AnimalFemaleHumansMethicillin-Resistant Staphylococcus aureusMiceStaphylococcus aureusStaphylococcal Vaccinesbiomaterialsimmunoengineeringorthopedic device infectionStaphylococcus aureusvaccination

Identifiers

PMID41183185
PMCPMC12625851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.