Evidence map›Paper›PMID 41183177›Full record

ArticleACS applied bio materials2025

Mesoporous Silica Nanoparticles for Quercetin-Controlled Delivery to Protect Cisplatin-Induced Ototoxicity.

Muyao Shen, Handong Wang, Junfeng Liu, Zixin Zhou, Xingguang Wu, Hanqi Fan, Haoliang Du, Yue Qiu, Dingding Liu, Dengbin Ma and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Muyao ShenDepartment of Otorhinolaryngology-Head and Neck Surgery, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing 210046, China.ORCID 0000-0001-8712-7511
Handong WangDepartment of Otolaryngology-Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Junfeng LiuMOE Key Laboratory of Intelligent Biomanufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, China.
Zixin ZhouDepartment of Otolaryngology-Head and Neck Surgery, Gulou Clinical Medical College, Jiangsu University, Zhenjiang 212000, China.
Xingguang WuDepartment of Otolaryngology-Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Hanqi FanDepartment of Otolaryngology-Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Haoliang DuDepartment of Otolaryngology-Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Yue QiuDepartment of Otolaryngology-Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Dingding LiuDepartment of Otolaryngology-Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Dengbin MaDepartment of Otolaryngology-Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Yong WangDepartment of Otorhinolaryngology, Jiangsu Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing 210028, China.
Zhao TangDepartment of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Shu YangThe First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing 210029, China.
Yuan ZhangDepartment of Otolaryngology-Head and Neck Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Tianhong ZhangDepartment of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China.
Xia GaoDepartment of Otorhinolaryngology-Head and Neck Surgery, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing 210046, China.ORCID 0000-0002-4539-5929

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cisplatin (CDDP), a widely used chemotherapeutic agent, is limited by severe ototoxicity side effects. Local drug delivery via the middle ear represents the most effective approach for treating inner ear disease. However, therapeutic efficacy is constrained by poor middle ear retention and limited permeability across the round window membrane (RWM). Quercetin (QU) exhibits potent activity against CDDP-induced cytotoxicity but suffers from delivery challenges. To address this, we developed amino-functionalized mesoporous silica nanoparticles (NH

Indexed as

Antineoplastic AgentsBiocompatible MaterialsCisplatinNanoparticlesOtotoxicityQuercetinSilicon DioxideAnimalsApoptosisDrug CarriersDrug Delivery SystemsHumansMaterials TestingMiceParticle SizePorosityAntineoplastic AgentsBiocompatible MaterialsCisplatinDrug CarriersQuercetinSilicon Dioxidecisplatindrug deliveryhearing lossmesoporous silica nanoparticlesototoxicityquercetin

Identifiers

PMID41183177
PMCPMC12628335

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.