Evidence map›Paper›PMID 41183169›Full record

ArticleACS nano2025

Toward a ToxAtlas of Carbon-Based Nanomaterials: Single-Cell RNA Sequencing Reveals Initiating Cell Circuits in Pulmonary Inflammation.

Carola Voss, Lianyong Han, Meshal Ansari, Maximilian Strunz, Verena Haefner, Ilias Angelidis, Christoph H Mayr, Trine Berthing, Qiaoxia Zhou, Eva M Guenther and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Carola VossInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Neuherberg 85764, Germany.ORCID 0000-0001-5243-4415
Lianyong HanInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Neuherberg 85764, Germany.ORCID 0000-0001-8623-776X
Meshal AnsariInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Neuherberg 85764, Germany.
Maximilian StrunzInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Neuherberg 85764, Germany.
Verena HaefnerInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Neuherberg 85764, Germany.
Ilias AngelidisInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Neuherberg 85764, Germany.
Christoph H MayrInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Neuherberg 85764, Germany.
Trine BerthingNational Research Centre for the Working Environment, Copenhagen 2100, Denmark.ORCID 0000-0003-0723-9869
Qiaoxia ZhouInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Neuherberg 85764, Germany.
Eva M GuentherInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Neuherberg 85764, Germany.
Osama HuzainInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Neuherberg 85764, Germany.
Otmar SchmidInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Neuherberg 85764, Germany.
Ulla VogelNational Research Centre for the Working Environment, Copenhagen 2100, Denmark.ORCID 0000-0001-6807-1524
Janine Gote-SchnieringInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Neuherberg 85764, Germany.
Svenja GaedckeBiomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover 30625, Germany.
Fabian J TheisDepartment of Computational Health, Institute of Computational Biology, Helmholtz Center Munich, Neuherberg 85764, Germany.
Herbert B SchillerInstitute of Experimental Pneumology, LMU University Hospital, Ludwig-Maximilians University, Munich 81377, Germany.
Tobias StoegerInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Center Munich, Neuherberg 85764, Germany.ORCID 0000-0002-2790-0389

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding how nanomaterial properties drive acute lung inflammation is critical for the development of safer materials, but for low solubility carbon-based nanomaterials (CBNs) the initiation of the inflammatory response is still poorly understood. Leveraging single-cell RNA sequencing of mouse lungs, 12 h after intratracheally instillation with different CBN spherical carbon nanoparticles (CNP), tangled double-walled (DWCNT), and rigid multiwalled carbon nanotubes (MWCNT) and lipopolysaccharide (LPS) as positive control, we identified 41 cell states and delineated material-specific molecular initiation events at single-cell resolution. CBN doses were chosen to cause equal levels of moderate inflammation, assessed by airspace neutrophilia, and exposure-triggered cellular activation was tested for

Indexed as

CarbonNanostructuresNanotubes, CarbonPneumoniaSequence Analysis, RNASingle-Cell AnalysisAnimalsLungMiceMice, Inbred C57BLCarbonNanotubes, Carbonmode of action (MoA)/cell circuitsnanomaterialspredictive assayspulmonary inflammationrespiratory toxicologyscRNA-seqToxAtlas

Identifiers

PMID41183169
PMCPMC12632174

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.