Evidence map›Paper›PMID 41183145›Full record

ArticleCirculation. Genomic and precision medicine2025

Precision Medicine and the FDA Modernization Act 2.0: Catalyzing Innovation in Cardiovascular Therapy.

Dominic E Fullenkamp, Lisa D Wilsbacher, Hanna J Tadros, Pankaj Arora, Thomas P Cappola

Abstract read
In one paragraph

Article in Circulation. Genomic and precision medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dominic E FullenkampCenter for Genetic Medicine (D.E.F., L.D.W.), Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0001-7627-7119
Lisa D WilsbacherCenter for Genetic Medicine (D.E.F., L.D.W.), Northwestern University Feinberg School of Medicine, Chicago, IL.ORCID 0000-0002-3676-0680
Hanna J TadrosDepartment of Pediatrics, Baylor College of Medicine, Houston, TX (H.J.T.).ORCID 0000-0002-2348-9262
Pankaj AroraSchool of Medicine, University of Alabama at Birmingham, AL (P.A.).ORCID 0000-0003-2420-3550
Thomas P CappolaUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, PA (T.P.C.).ORCID 0000-0002-9630-7204

Funding

MTSS1 in Myocardial DiseaseR01HL141232 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI THOMAS P. CAPPOLA, Scott Michael Damrauer · 2019 to 2026
$4.7M
Natriuretic Peptide-Renin-Angiotensin-Aldosterone System Rhythm Axis and Nocturnal Blood PressureR01HL160982 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Pankaj Arora · 2022 to 2026
$3.7M
Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological StudyR01HL163081 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Pankaj Arora · 2022 to 2026
$3.7M
The Effects of Neprilysin Inhibition on Cardiometabolic Health in Black IndividualsR01HL163852 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Pankaj Arora · 2022 to 2026
$3.6M
Methods for Enhancing Polygenic Risk Prediction Models for Complex DiseaseR01HL169458 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Dokyoon Kim, MARYLYN D RITCHIE · 2023 to 2026
$3.1M
Risk Alleles in Protein Quality Control Genes as Modifiers of Hypertrophic CardiomyopathyR01HL168841 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Sharlene M Day · 2024 to 2026
$2.2M
Clinical Implementation of Blood Pressure Polygenic Risk Score: A Randomized Clinical TrialR01HL176882 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Pankaj Arora · 2025 to 2026
$1.5M
Physiologic stress in advanced tissue culture models of cardiomyopathyK08HL163392 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Dominic Edward Fullenkamp · 2023 to 2026
$656k
Mentored Patient-Oriented Research in Natriuretic Peptide System Based Precision Cardiometabolic HealthK24HL180320 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Pankaj Arora · 2025 to 2026
$265k
NHLBI NIH HHS K08 HL163392NHLBI NIH HHS K24 HL180320NHLBI NIH HHS R01 HL141232NHLBI NIH HHS R01 HL160982NHLBI NIH HHS R01 HL163081NHLBI NIH HHS R01 HL163852NHLBI NIH HHS R01 HL168841NHLBI NIH HHS R01 HL169458NHLBI NIH HHS R01 HL176882
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cardiovascular diseasesgeneticsprecision medicinestem cellsUnited States Food and Drug Administration

Identifiers

PMID41183145
PMCPMC12788729

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.