ArticlePloS one2025
Exploring the genetic landscape of the Copper Homeostasis and Silver Resistance Island (CHASRI) in Salmonella enterica.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Genomic Epidemiology of FoodborneAntibiotics (Basel, Switzerland) · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copper is essential for all living organisms, but becomes toxic when present in excess. Biological systems have evolved mechanisms to keep organisms in copper homeostasis. Studies have shown that Salmonella can acquire mobile genetic elements that provide enhanced tolerance to stressed environments, such as the Copper Homeostasis and Silver Resistance Island (CHASRI), which has become more prevalent in certain serovars that are exposed to higher levels of copper. In this study, whole genome sequence data available from NCBI Pathogen Detection was used to determine the incidence of the CHASRI is in Salmonella enterica isolates. The results show that the CHASRI is present in a wider range of serovars than previously known and can be found in isolates from different food sources, including nuts, spices, and produce. Salmonella Genomic Island-4 (SGI-4) was previously described as the primary mobile element through which the CHASRI was transferred to Salmonella; however, results from this comparative study of closed reference genomes identified additional integrations of the CHASRI as both a singular mobile element and as a component of an SGI-4 variant.
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