ArticleeLife2025
Relative timescale of channel voltage dependence and channel density regulation impacts assembly and recovery of activity.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Sensitivity of a model oscillator to shifts in the voltage-dependence of one or more ionic currents.Journal of neurophysiology · 2026Article
- Persistent adaptation through dual-timescale regulation of ion channel properties.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
Neurons can maintain stable activity profiles over their lifetimes despite ion channel turnover over minutes to weeks. Neuronal activity is also influenced by regulating the voltage dependence of ion channels. How do these two forms of plasticity work together to maintain a stable activity profile? We augment a classical model of activity-dependent ion channel density regulation with a mechanism that adjusts channel voltage dependence based on activity. These findings reveal that the timescale of these mechanisms shapes the specific electrical activity patterns that achieve a target activity profile. Moreover, alterations in channel voltage dependence can impact a neuron's ability to recover from perturbations. These results highlight a potentially distinct role for activity-dependent regulation of channel voltage dependence in maintaining stable neuronal activity profiles.
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Registered trials
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