ArticleProbiotics and antimicrobial proteins2026
Lactiplantibacillus Plantarum Postbiotics Suppress Salmonella Typhimurium Invasion and Modulate Innate Responses in Human Intestinal Epithelial Cells.
Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Healthy Nutrition and Fermented Animal-Sourced Foods as a Complementary One Health Strategy: Effects on Foodborne Pathogens and Intestinal Host Defense.Journal of clinical practice and research · 2026Review
- Microbiota-Derived Regulation of AhR and VDR Signaling in Intestinal Inflammation: Protective Roles of Prebiotics, Probiotics, and Postbiotics.International journal of molecular sciences · 2026Review
- Antibacterial Immunotherapy: Mechanistic Insights, Emerging Therapeutic Strategies, and Clinical Translation.Infection and drug resistance · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Postbiotics derived from Lactiplantibacillus plantarum (LPP) exhibit promising potential as safe modulators of intestinal health. Here, the chemical, antimicrobial, and host-regulatory properties of LPP against Salmonella enterica serovar Typhimurium were investigated using a human intestinal epithelial (Caco-2) cell model. The LPP exhibited broad-spectrum antimicrobial activity against major foodborne pathogens, with minimal inhibitory concentrations ranging between 12.5 and 25 mg/mL. Treatment of Caco-2 cells with sub-MIC doses of LPP (6.25 mg/mL) significantly suppressed intracellular invasion of Salmonella (P < 0.05). Gene expression analysis revealed consistent downregulation of NF-κB gene expression following LPP presence with sublethal doses (P < 0.001), while no significant changes were detected in the expression levels of other key proinflammatory cytokines during the early phases (six and 12 h) of infection. A significant increase (P < 0.001) in apoptotic cell rates occurred at six h post-infection (PI), while no significant differences were observed at 12 h PI. The results revealed that LPP not only suppresses Salmonella invasion but also shows time-dependent modulation of inflammatory signaling and apoptotic responses in intestinal epithelial cells. These observed effects can be attributed to the bioactive compounds present in LPP, including organic acids, free amino acids, free fatty acids, polyphenols, and volatiles. The findings suggest that L. plantarum postbiotics can attenuate bacterial invasion and modulate innate immune response mechanisms without compromising host cell viability.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.