Evidence map›Paper›PMID 41182644›Full record

ReviewCurrent medical science2025

Multifaceted Roles of Bcl-2 Family Proteins: Regulatory Roles in Apoptosis, Physiological Functions, and Therapeutic Potential.

Nisreen Salah Majeed, Asmaa A Salam, Shahd Rajab Farhan, Sumaya Ayad Abdulrazzaq, Soumya V Menon, Mandeep Kaur, Mandeep Singh, Beneen Husseen, Mohammed Abed Jawad, Razzagh Abedi-Firouzjah

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nisreen Salah MajeedCollege of Medicine, University of Anbar, Ramadi, 31001, Iraq. nisreen.salah@uoa.edu.iq.
Asmaa A SalamBiology Department, College of Education, University of Fallujah, Fallujah, 31002, Iraq.
Shahd Rajab FarhanBiotechnology Department, College of Applied Science, Fallujah University, Fallujah, 31002, Iraq.
Sumaya Ayad AbdulrazzaqCenter of Desert Studies, University of Anbar, Ramadi, Anbar, 31001, Iraq.
Soumya V MenonDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, 562112, India.
Mandeep KaurDepartment of Sciences, Vivekananda Global University, Jaipur, Rajasthan, 303012, India.
Mandeep SinghDirectorate of Physical Education and Sports, University of Kashmir, Srinagar, 180006, India.
Beneen HusseenMedical Laboratory Technique College, The Islamic University, Najaf, 54001, Iraq.
Mohammed Abed JawadDepartment of Pharmaceutics, Al-Nisour University College, Baghdad, 10013, Iraq.
Razzagh Abedi-FirouzjahDepartment of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran. razzaghabedi@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bcl-2 family proteins (BFPs) are essential regulators of regulated cell death (RCD), and their dysregulation is implicated in a wide range of disorders, including cancer, neurodegenerative diseases, and autoimmune conditions. Recent studies have shown that BFPs also play critical roles in autophagy, calcium homeostasis, neuronal function, and mitochondrial dynamics, underscoring their multifaceted contributions to cellular health. In this review, we summarize the current knowledge concerning the physiological roles and structural diversity of BFPs, with a particular focus on key multidomain proteins such as Bak, Bax, and Bok. Our findings highlight persistent challenges and knowledge gaps, especially concerning the interactions between BFPs and diverse cellular pathways. In conclusion, BFPs act as fundamental regulators of cell survival and apoptosis. While significant progress has been made in elucidating their molecular mechanisms, important questions remain-particularly regarding the precise structural dynamics of pore formation, the influence of the mitochondrial lipid composition, and the balance between pro- and anti-apoptotic members. Finally, the therapeutic potential of BFP-targeted drugs, including BH3 mimetics, offers promising avenues for treating cancer and other diseases characterized by aberrant regulation of apoptosis.

Indexed as

ApoptosisNeoplasmsProto-Oncogene Proteins c-bcl-2AnimalsAutophagybcl-2-Associated X Proteinbcl-2 Homologous Antagonist-Killer ProteinHumansMitochondriaNeurodegenerative Diseasesbcl-2-Associated X Proteinbcl-2 Homologous Antagonist-Killer ProteinProto-Oncogene Proteins c-bcl-2ApoptosisBakBaxBcl-2BH3 mimeticsCell death regulationMitochondrial dynamicsTherapeutic target

Identifiers

PMID41182644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.