[Wells Syndrome: Clinical Presentation and Literature Review].

Introduction: Eosinophilic cellulitis, also known as Wells syndrome, is a rare inflammatory dermatosis that mimics skin infections such as bacterial cellulitis, often leading to delays in proper diagnosis and treatment. The aim of this report is to present a clinical case of Wells syndrome and review the main clinical, histopathological, and therapeutic findings associated with this condition. Clinical case: A 24-year-old female patient with no relevant medical history presented with a two-month history of a dermatosis localized on the right side of the face, characterized by an erythematous-edematous plaque. She was initially treated as a case of infectious cellulitis with antibiotics, without clinical improvement. A skin biopsy was performed, revealing an eosinophilic inflammatory infiltrate with flame figures, confirming the diagnosis of eosinophilic cellulitis. Treatment with prednisone was initiated, resulting in complete resolution of the lesions and no recurrences during follow-up. Conclusions: Wells syndrome should be considered in patients with chronic inflammatory dermatoses that do not respond to antibiotics. Skin biopsy is essential for diagnosis, and systemic corticosteroids are an effective treatment. Recognizing this entity helps avoid unnecessary treatments and improves prognosis through timely therapeutic intervention.