Evidence map›Paper›PMID 41182619›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Software and Tools to Analyze High-Density Peptide Array Data for the Chagas Antigen and Epitope Atlas.

Guadalupe Romer, Ramiro B Quinteros, Fernán Agüero

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Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Guadalupe RomerInstituto de Investigaciones Biotecnológicas (IIBIO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Martín, Argentina.
Ramiro B QuinterosInstituto de Investigaciones Biotecnológicas (IIBIO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Martín, Argentina.
Fernán AgüeroInstituto de Investigaciones Biotecnológicas (IIBIO), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Martín, Argentina. fernan@iib.unsam.edu.ar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trypanosoma cruzi produces a long-lasting and diverse antibody response in infected hosts. Recently, with the advent of high-density peptide microarrays, millions of peptides from the complete proteomes of two T. cruzi strains were subjected to extensive immune profiling revealing thousands of discrete antibody-binding peaks and antigenic regions in proteins, from infected human hosts across diverse human populations. Furthermore, hundreds of the identified epitopes were subjected to redundant site-specific mutagenesis to reveal residues important for antibody-binding in these epitopes. This chapter provides software and tools to analyze peptide microarray data in this context and also guiding examples to allow users to re-analyze data in their own ways.

Indexed as

Antigens, ProtozoanChagas DiseaseEpitopesProtein Array AnalysisSoftwareTrypanosoma cruziEpitope MappingHumansPeptidesAntigens, ProtozoanEpitopesPeptidesAntigen discoveryChagas diseaseCHAGASTOPEEpitope characterizationEpitope mappingPeptide arraysTrypanosoma cruzi

Identifiers

PMID41182619

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.