ArticleProgress in orthodontics2025
Evaluation of the stability of immediately reinserted orthodontic miniscrews using a novel bioactive adhesive composite: an in vivo animal study.
Article in Progress in orthodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate the effectiveness of a novel bioactive adhesive composite-comprising chitosan (CS), nanohydroxyapatite (nHA), β-tricalcium phosphate (β-TCP), and postbiotics-in enhancing the stability of orthodontic miniscrews immediately reinserted following failure in the same insertion site using a new miniscrew in an in vivo rat femur model. METHODOLOGY: Composite adhesives were prepared in two distinct forms: foam and paste. Orthodontic miniscrews were placed into the left femurs of 28 male Sprague‒Dawley rats, and a small hole was drilled 15 mm distal to the miniscrew site. Orthodontic force was applied via a 100-gram Ni‒Ti closed coil spring attached between the miniscrew and the drilled hole. After 4 weeks, the rats were divided into four groups: Group 1 (4-week control), Group 2 (8-week control), Group 3 (paste adhesive), and Group 4 (foam adhesive). Group 1 rats were euthanized to assess primary miniscrew stability. Groups 2, 3, and 4 underwent a second surgery in which miniscrews were carefully removed and reinserted without adhesive, with paste-form adhesive, and with foam-form adhesive, respectively. After an additional 4 weeks, miniscrew stability was evaluated through histological analysis and mechanical pull-out testing. The data were analyzed via one-way ANOVA followed by Duncan's post hoc test. Normality was confirmed with the Shapiro‒Wilk test, and effect sizes (Eta Squared) were calculated due to the small sample size.
resultsReinsertion without adhesive reduced the stability of miniscrews. However, when adhesive was used during reinsertion, the maximum force required to extract the miniscrew from the surrounding bone significantly increased, with the foam group demonstrating the highest pull-out strength (PS). Compared with the control group, the paste and foam groups presented greater mean bone‒implant contact (BIC) and bone volume (BV) values, although these differences were not statistically significant (p > 0.05). Effect size analysis revealed large differences in the clinical effects of BV and PS between the control groups and the adhesive-treated groups.
conclusionsThe bioactive adhesive composite can improve the primary stability of orthodontic miniscrews immediately reinserted into the same site after failure. The findings suggest that such adhesives may serve as a temporary adjunct to support anchorage continuity, warranting further in vivo evaluation before clinical application.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.