Evidence map›Paper›PMID 41182572›Full record

ArticleSports medicine (Auckland, N.Z.)2026

Incidence of and Risk Factors for Lower Extremity Apophysitis in Children and Adolescents.

Niels Wedderkopp, Chinchin Wang, Russell Steele, Jeff Hebert, Christina Rexen, Eva Jespersen, Tina Junge, Tobias Thomsen, Frederik Mølgaard Jensen, Ian Shrier

Registry-linked trialAbstract read
In one paragraph

Article in Sports medicine (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03510494 (The Childhood Health, Activity, and Motor Performance School Study Denmark), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03510494 nacompletednot on this map

The Childhood Health, Activity, and Motor Performance School Study Denmark

TypeinterventionalSponsorUniversity of Southern DenmarkRan2008 to 2015Enrolled1,209ConditionsObesity, Childhood, Risk Factor, Cardiovascular, Sports Injury, Physical ActivityArmsAugmented physical education program
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Niels WedderkoppThe Pediatric Research Unit, Department of Clinical Research, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark. nwedderkopp@health.sdu.dk.ORCID 0000-0002-9660-6618
Chinchin WangDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada.
Russell SteeleDepartment of Mathematics and Statistics, McGill University, Montreal, Canada.ORCID 0000-0003-1071-0914
Jeff HebertFaculty of Kinesiology, University of New Brunswick, Fredericton, Canada.
Christina RexenDepartment of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.ORCID 0000-0003-0301-9922
Eva JespersenDepartment of Rehabilitation, Odense University Hospital, Odense, Denmark.ORCID 0000-0002-8942-4816
Tina JungeDepartment of Applied Health Research, University College Lillebaelt, Odense, Denmark.ORCID 0000-0002-3304-3010
Tobias ThomsenDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.
Frederik Mølgaard JensenDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.
Ian ShrierCentre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Canada.ORCID 0000-0001-9914-3498

Funding

Nordea-fonden 02--2011--3679
6 · The paper itself

Abstract

introductionApophysitis is a common musculoskeletal injury in children and adolescents often resulting in pain and deformity such as bony prominences in Osgood-Schlatter, leading to reduced physical function. A concerning consequence of lower extremity (LE) apophysitis is its potential to reduce physical activity.

objectivesWe aimed to describe the incidence of lower extremity apophysitis in children and estimate the association of leisure-time sport (LT-sport) participation and physical education (PE) on apophysitis incidence.

methodsIn a 5.5-year prospective cohort study of primary-school students, parents sent weekly text messages reporting injury occurrences and LT-sport participation data in the participating children. Injury reports triggered subsequent clinical evaluation.

resultsWe analyzed data from 878 girls and 792 boys and identified 1265 episodes of apophysitis in 1670 children. Sever's, Sinding-Larsen-Johansson's, and Osgood-Schlatter's diseases constituted more than 99% of LE-apophysitis cases. The median time of injury duration was 3-4 weeks, and the range was between 1 and 45 weeks. The incidence was between 3.2 and 7.0 cases of LE apophysitis per 1000 LT-sport participations. Extra physical education did not increase the risk of apophysitis, whereas children who participated in soccer, handball, basketball, and jump gymnastics were at increased risk (risk ratio [RR] = 2.07-2.74).

conclusionsLower extremity apophysitis can result in months of pain. This is important as prolonged periods of injury could reduce LT-sport and exercise participation, thereby decreasing health-related physical activity in childhood. Our results suggest early diagnosis and activity modification in children and adolescents with apophysitis may reduce injury duration, but future intervention studies are required before more definitive causal conclusions can be drawn.

trial registrationDanish Data Protection Agency (J. no. 2008-41-2240) and ClinicalTrials.gov (NCT03510494).

Indexed as

Athletic InjuriesLower ExtremityAdolescentChildFemaleHumansIncidenceMalePhysical Education and TrainingProspective StudiesRisk Factors

Identifiers

PMID41182572
PMCPMC13018006

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.