Evidence map›Paper›PMID 41182562›Full record

ArticleHepatology international2026

SOX9 promotes hepatocyte proliferation via upregulating TGF-α expression during liver regeneration.

Shu-Qing Liu, Hai-Lin Xiong, Chuan Yin, Xing Deng, Kai Ding, Mei-Tong Nie, Meng-Chao Xiao, Chang-Peng Zhu, Xia-Lu Hong, Chen-Hong Ding and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Hepatology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Dynamic activation and dual roles of SOX9Frontiers in cell and developmental biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shu-Qing Liu *Department of Gastroenterology, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai, 200003, China.
Hai-Lin Xiong *Department of Gastroenterology, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai, 200003, China.
Chuan Yin *Department of Gastroenterology, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai, 200003, China.
Xing DengDepartment of Gastroenterology, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai, 200003, China.
Kai DingDepartment of Gastroenterology, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai, 200003, China.
Mei-Tong NieDepartment of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China.
Meng-Chao XiaoDepartment of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai, 200120, China.
Chang-Peng ZhuDepartment of Gastroenterology, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai, 200003, China.
Xia-Lu HongDepartment of Gastroenterology, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai, 200003, China.
Chen-Hong DingDepartment of Gastroenterology, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai, 200003, China.
Ke-Qi WangDepartment of Gastroenterology, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai, 200003, China.
Wei-Fen XieDepartment of Gastroenterology, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai, 200003, China. weifenxie@medmail.com.cn.
Xin ZhangDepartment of Gastroenterology, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai, 200003, China. zhang68@hotmail.com.ORCID http://orcid.org/0000-0001-5712-6614

Funding

National Natural Science Foundation of China 82070645National Natural Science Foundation of China 82200678National Natural Science Foundation of China 82273096Natural Science Foundation of Shanghai Municipality 22ZR1477400Scientific Research Project of the Shanghai Municipal Health Bureau 202140335
6 · The paper itself

Abstract

backgroundThe liver possesses a remarkable capacity for regeneration. Previous studies have shown that SOX9/HNF4α double-positive hepatocytes play a role in chronic liver injury. Furthermore, the deletion of HNF4α results in prolonged hepatocyte proliferation following partial hepatectomy. However, the precise role of SOX9 in liver regeneration remains poorly understood.

methodsWe established acute liver injury models using standard partial hepatectomy (sHx), extended partial hepatectomy (eHx), and intraperitoneal injection of carbon tetrachloride (CCl

resultsOur study found that SOX9 expression was increased, while HNF4α expression decreased in the priming phase of acute liver injury. HNF4α suppressed SOX9 expression by upregulating miR-124/381 in hepatocytes. Deletion of SOX9 in hepatocytes resulted in a reduced liver-to-body weight ratio and impaired hepatocyte proliferation in both sHx- and CCl

conclusionsOur findings revealed that HNF4α negatively regulates SOX9 and demonstrated that SOX9 promotes hepatocyte proliferation by upregulating TGF-α levels, ultimately enhancing liver regeneration.

Indexed as

HepatocytesLiver RegenerationSOX9 Transcription FactorTransforming Growth Factor alphaAnimalsCell ProliferationDisease Models, AnimalHepatectomyHepatocyte Nuclear Factor 4MaleMiceMice, Inbred C57BLMice, KnockoutUp-RegulationHepatocyte Nuclear Factor 4Hnf4a protein, mouseSox9 protein, mouseSOX9 Transcription FactorTransforming Growth Factor alphaAcute liver injuryCell communicationEpidermal growth factorHepatocyteHepatocyte nuclear factors-4 alphamicroRNAParacrinePartial hepatectomySingle-nucleus RNA sequencingTranscriptional regulation

Identifiers

PMID41182562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.