Evidence map›Paper›PMID 41182498›Full record

ReviewJournal of neuro-oncology2025

Redefining the therapeutic landscape of glioblastomas and brain metastasis through cesium brachytherapy and low-kV intra-operative radiation therapy (IORT).

Carlin Chuck, Abigail Teshome, Alice Lin, Sumaiya Sayeed, Elaina Wang, Natalie Amaral-Nieves, Mazen Taman, Joseph Oldam, Hsien-Chung Chen, Brijal Desai and 7 more

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Carlin ChuckDepartment of Neurosurgery, Warren Alpert School of Brown University, 593 Eddy Street - APC 6, Providence, RI, 02903, USA.
Abigail TeshomeWarren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Alice LinWarren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Sumaiya SayeedDepartment of Neurosurgery, Warren Alpert School of Brown University, 593 Eddy Street - APC 6, Providence, RI, 02903, USA.
Elaina WangDepartment of Neurosurgery, Warren Alpert School of Brown University, 593 Eddy Street - APC 6, Providence, RI, 02903, USA.
Natalie Amaral-NievesDepartment of Neurosurgery, Warren Alpert School of Brown University, 593 Eddy Street - APC 6, Providence, RI, 02903, USA.
Mazen TamanWarren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Joseph OldamWarren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Hsien-Chung ChenDepartment of Neurosurgery, Warren Alpert School of Brown University, 593 Eddy Street - APC 6, Providence, RI, 02903, USA.
Brijal DesaiDepartment of Radiation Oncology, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Andrew KopeckyDepartment of Radiation Oncology, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Mark J RivardDepartment of Radiation Oncology, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Sasmit SarangiDepartment of Neurology, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Heinrich ElinzanoDepartment of Neurology, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Eric T WongDepartment of Neurology, Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA.
Christopher P CifarelliDepartments of Neurosurgery and Radiation Oncology, West Virginia University, Morgantown, WV, 26506, USA.
Clark C ChenDepartment of Neurosurgery, Warren Alpert School of Brown University, 593 Eddy Street - APC 6, Providence, RI, 02903, USA. clark_chen@brown.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of brachytherapy in neuro-oncology has evolved through periods of enthusiasm and skepticism.

objectiveWe examined the historical landscape of brachytherapy, tracing influential studies, clinical adoption patterns, technological advancements, and ongoing trials that reflect its resurgence in neuro-oncology.

methodsWe conducted a scoping literature review of brachytherapy.

resultsBecause of their favorable safety profiles, cesium-131brachytherapy and low-kV intra-operative radiation therapy (IORT) have emerged as a preferred platform for intracranial brachytherapy. In glioblastoma and brain metastasis (BM) patients, published literature indicates that cesium-131 brachytherapy and low-kV IORT do not increase the risk of surgical morbidity or procedural complications. Radiation necrosis remains rare in most glioblastoma and brain metastasis cases. Consistent across the available literature, cesium-131 brachytherapy and low-kV IORT are associated with excellent local control, including large lesions with a maximal diameter of > 3.5 cm. Ongoing clinical trials aim to compare the effectiveness of these adjunctive radiation platforms to the current standard of care, while also exploring their potential for integration into multimodal treatment strategies.

conclusionAs prospective clinical trials mature, cesium-131 brachytherapy and IORT are poised to redefine the therapeutic landscape for glioblastoma and brain metastasis management.

Indexed as

BrachytherapyBrain NeoplasmsCesium RadioisotopesGlioblastomaHumansCesium-131Cesium RadioisotopesBrachytherapyBrain metastasis (BM)CesiumGlioblastomaIntra-operative radiation therapy (IORT)

Identifiers

PMID41182498

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.