ArticleDiscover oncology2025
Mendelian randomization analysis: causal link between hyperthyroidism/thyrotoxicosis and ovarian cancer.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundThe purpose of this study was to use a two-sample Mendelian randomization (MR) approach to explore the causal link between hyperthyroidism/thyrotoxicosis and ovarian cancer (OC).
methodsBy leveraging genome-wide association study (GWAS) data from publicly available databases, we identified single nucleotide polymorphisms (SNPs) representing genetic variants for both hyperthyroidism/thyrotoxicosis and OC. We employed the inverse variance weighted method (IVW) to assess the association between hyperthyroidism/thyrotoxicosis and the risk of OC. Further, we evaluated SNP heterogeneity using the Cochran's Q test and detected the presence of outlier SNPs using the MR-PRESSO test. To examine the pleiotropy of SNPs, we employed the MR-Egger intercept test. Additionally, a "leave-one-out" sensitivity analysis was conducted to assess the influence of individual SNPs on the MR results. Finally, we performed a reverse MR analysis to explore the possibility of reverse causality.
resultsThe results of the IVW analysis indicated a causal relationship between hyperthyroidism/thyrotoxicosis and OC, with hyperthyroidism/thyrotoxicosis increasing the incidence of OC (p < 0.05). According to the MR-Egger intercept and MR-PRESSO global tests, no horizontal pleiotropy was observed in this study (P > 0.05). Sensitivity analysis using "leave-one-out" method indicated the stability of these genetic variants.
conclusionsOur systematic analyses provide evidence supporting a potential causal relationship between hyperthyroidism/thyrotoxicosis and the risk of OC.
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