Evidence map›Paper›PMID 41182415›Full record

ArticleNeuroradiology2025

Prolonged venous transit and clinical outcomes in anterior circulation large-vessel occlusion stroke with complete or near-complete reperfusion.

Hamza Adel Salim, Dhairya A Lakhani, Aneri Balar, Janet Mei, Licia Luna, Mona Shahriari, Nathan Z Hyson, Francis Deng, Adam A Dmytriw, Adrien Guenego and 15 more

Abstract read
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Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Hamza Adel Salim *Department of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA. Hamza.sleeem@gmail.com.
Dhairya A Lakhani *Department of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Aneri BalarDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Janet MeiDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Licia LunaDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Mona ShahriariDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Nathan Z HysonDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Francis DengDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Adam A DmytriwNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Adrien GuenegoDepartment of Diagnostic and Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium.
Victor C UrrutiaDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Elisabeth B MarshDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Hanzhang LuDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Risheng XuDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Rich LeighDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Gaurang ShahDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
Sijin WenDepartment of Epidemiology and Biostatistics , West Virginia University, Morgantown, WV, USA.
Gregory W AlbersDepartment of Interventional Neuroradiology, Stanford Medical Center, Palo Alto, CA, USA.
Argye E HillisDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Rafael LlinasDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA.
Kambiz NaelDepartment of Radiology & Biomedical Imaging, University of California, San Francisco, CA, USA.
Max WintermarkDepartment of Neuroradiology, MD Anderson Medical Center, Houston, TX, 77030, USA.
Jeremy J HeitDepartment of Interventional Neuroradiology, Stanford Medical Center, Palo Alto, CA, USA.
Tobias D FaizyDepartment of Radiology, Neuroendovascular Program, University Medical Center Münster, ., Germany.
Vivek YedavalliDepartment of Radiology, Division of Neuroradiology, Johns Hopkins Medical Center, Baltimore, MD, USA. vyedava1@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProlonged venous transit (PVT), indicative of impaired venous outflow, is linked to poor outcomes in acute ischemic stroke due to large-vessel occlusion (AIS-LVO) treated with mechanical thrombectomy (MT). This study investigated the prognostic significance of PVT in AIS-LVO patients achieving near-complete or complete reperfusion (mTICI 2c or 3).

methodsRetrospective analysis of a prospective registry included AIS-LVO patients with anterior circulation occlusions, mTICI 2c or 3 after MT, and 90-day modified Rankin Scale (mRS) scores. PVT, defined as Tmax ≥ 10 s in the posterior superior sagittal sinus or torcula on pretreatment CT perfusion, was assessed. Outcomes were favorable recovery (mRS 0-2), excellent recovery (mRS 0-1), and 90-day mortality.

resultsAmong 81 patients, 25 (31%) were PVT + and 56 (69%) were PVT-. Baseline characteristics were similar. PVT + patients had higher discharge NIH Stroke Scale scores and worse 90-day mRS scores (median mRS, 4.00 vs. 1.00; P < 0.001). Multivariable analysis showed PVT + independently predicted lower odds of favorable (OR, 0.18; 95% CI, 0.04-0.65; P = 0.013) and excellent outcomes (OR, 0.12; 95% CI, 0.02-0.52; P = 0.008) and higher 90-day mortality (OR, 4.11; 95% CI, 1.08-17.0; P = 0.041).

conclusionsPVT is a strong negative prognostic marker in AIS-LVO patients with excellent reperfusion, associated with reduced functional recovery and increased 90-day mortality. PVT assessment may identify high-risk patients despite successful MT.

Indexed as

Ischemic StrokeThrombectomyAgedComputed Tomography AngiographyFemaleHumansMaleMiddle AgedPrognosisRegistriesReperfusionRetrospective StudiesTreatment OutcomeCTPProlonged venous transitStroke

Identifiers

PMID41182415

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.