Evidence map›Paper›PMID 41182351›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2026

Serum L-ornithine-derived polyamines as indicators of Parkinson disease progression.

Peter A LeWitt, Jia Li, Peggy Auinger, Parkinson Study Group DATATOP Investigators

Abstract read
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In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Peter A LeWittDepartments of Neurology and Pharmacology, and Sastry Foundation Endowed Chair in Parkinson Disease Research, Wayne State University School of Medicine, 4201 St. Antoine Street, UHC-8D, Detroit, MI, 48202, USA. aa1142@wayne.edu.ORCID http://orcid.org/0000-0002-4976-4445
Jia LiDepartment of Public Health Science, Henry Ford Hospital, Detroit, MI, USA.
Peggy AuingerCenter for Health and Technology, University of Rochester, Rochester, NY, USA.
Parkinson Study Group DATATOP Investigators

Funding

Michael J. Fox Foundation for Parkinson's Research Biomarkers Research Initiative
6 · The paper itself

Abstract

Prior studies reported that biospecimen concentrations of L-ornithine-derived polyamines (ODPAs) and their metabolites differentiated Parkinson disease (PD) from healthy controls. We investigated ODPA metabolism in CSF and serum specimens from well-characterized, unmedicated PD patients to explore correlations with disease severity, progression, and PD clinical subtypes using data from Unified PD Rating Scale (UPDRS) assessments. We developed targeted assays for L-ornithine and the ODPAs putrescine, spermine, spermidine, and the polyamine metabolites N

Indexed as

Disease ProgressionOrnithineParkinson DiseasePolyaminesAgedBiomarkersFemaleHumansMaleMiddle AgedSeverity of Illness IndexBiomarkersOrnithinePolyaminesBiomarkersL-ornithineNeurodegenerationParkinson diseasePolyaminePutrescineSpermidineSpermine

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.