Evidence map›Paper›PMID 41182344›Full record

Observational studyClinical research in cardiology : official journal of the German Cardiac Society2026

Diabetes-related ten-year outcomes after percutaneous coronary intervention of in-stent restenosis.

Constantin Kuna, Eduard Braun, Christian Bradaric, Tobias Koch, Antonia Presch, Felix Voll, Sebastian Kufner, Tareq Ibrahim, Heribert Schunkert, Karl-Ludwig Laugwitz and 3 more

Abstract readObservational StudyMulticenter Study
In one paragraph

Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Constantin KunaDepartment of Cardiology, Deutsches Herzzentrum München, Universitätsklinikum Der Technischen Universität München, Munich, Germany. kuna@dhm.mhn.de.ORCID http://orcid.org/0009-0007-0154-6514
Eduard BraunDepartment of Cardiology, Deutsches Herzzentrum München, Universitätsklinikum Der Technischen Universität München, Munich, Germany.
Christian BradaricClinic and Policlinic Internal Medicine I (Cardiology and Angiology), Universitätsklinikum Der Technischen Universität München, Klinikum Rechts Der Isar, Munich, Germany.
Tobias KochDepartment of Cardiology, Deutsches Herzzentrum München, Universitätsklinikum Der Technischen Universität München, Munich, Germany.
Antonia PreschDepartment of Cardiology, Deutsches Herzzentrum München, Universitätsklinikum Der Technischen Universität München, Munich, Germany.
Felix VollDepartment of Cardiology, Deutsches Herzzentrum München, Universitätsklinikum Der Technischen Universität München, Munich, Germany.
Sebastian KufnerDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Tareq IbrahimClinic and Policlinic Internal Medicine I (Cardiology and Angiology), Universitätsklinikum Der Technischen Universität München, Klinikum Rechts Der Isar, Munich, Germany.
Heribert SchunkertDepartment of Cardiology, Deutsches Herzzentrum München, Universitätsklinikum Der Technischen Universität München, Munich, Germany.
Karl-Ludwig LaugwitzDZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Salvatore CasseseDepartment of Cardiology, Deutsches Herzzentrum München, Universitätsklinikum Der Technischen Universität München, Munich, Germany.
Adnan KastratiDepartment of Cardiology, Deutsches Herzzentrum München, Universitätsklinikum Der Technischen Universität München, Munich, Germany.
Jens WiebeDepartment of Cardiology, Deutsches Herzzentrum München, Universitätsklinikum Der Technischen Universität München, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLimited data is available for long-term outcomes after percutaneous coronary intervention (PCI) of coronary drug-eluting stent (DES) in-stent restenosis (ISR) in diabetics.

aimsThus, the aim of this observational, retrospective study was to close this lack of evidence.

methodsBetween January 2007 and February 2021, a total of 3511 patients with 5497 ISR lesions were treated at two large-volume centers in Munich, Germany, of which 1242 (35.4%) were diabetics. Endpoints of interest were the rates of cardiac death, repeat revascularization, and myocardial infarction (MI). Survival was analyzed using the Kaplan-Meier method. Differences between the groups were tested with the log-rank test. Conventional multivariable analysis with adjustment for relevant variables was performed.

resultsAfter 10 years, the rates of cardiac death were 42.8% for diabetics and 32.8% for nondiabetics (HR

conclusionsIn the long term, the rates of cardiac death, MI, and repeat revascularization after PCI of DES-ISR are significantly higher in diabetics, particularly in insulin-dependent diabetics, than in nondiabetics.

Indexed as

Coronary Artery DiseaseCoronary RestenosisDiabetes MellitusDrug-Eluting StentsPercutaneous Coronary InterventionAgedFemaleFollow-Up StudiesGermanyHumansMaleMiddle AgedMyocardial InfarctionRetrospective StudiesRisk FactorsSurvival RateDiabetes mellitusDrug-coated balloonDrug-eluting stentIn-stent restenosisPercutaneous coronary intervention

Identifiers

PMID41182344
PMCPMC12783287

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.