Evidence map›Paper›PMID 41182265›Full record

ArticleGenetics2026

Xenbase: 25 years of integrating molecular and biomedical data from Xenopus.

Stanley Chu, Andrew J Bell, Vaneet Lotay, Ngoc Ly, Troy J Pells, Taejoon Kwon, Sergei Agalakov, Virgilio Ponferrada, Courtney Lenz, Christina James-Zorn and 9 more

Abstract read
In one paragraph

Article in Genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Stanley ChuDepartment of Biological Sciences, University of Calgary, Calgary, Alberta T2N1N4, Canada.
Andrew J BellDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.ORCID 0000-0002-8828-8402
Vaneet LotayDepartment of Biological Sciences, University of Calgary, Calgary, Alberta T2N1N4, Canada.
Ngoc LyDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.
Troy J PellsDepartment of Biological Sciences, University of Calgary, Calgary, Alberta T2N1N4, Canada.
Taejoon KwonDepartment of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.ORCID 0000-0002-9794-6112
Sergei AgalakovDepartment of Biological Sciences, University of Calgary, Calgary, Alberta T2N1N4, Canada.
Virgilio PonferradaDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.
Courtney LenzDepartment of Biological Sciences, University of Calgary, Calgary, Alberta T2N1N4, Canada.
Christina James-ZornDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.ORCID 0000-0001-5495-4588
Brad ArshinoffDepartment of Biological Sciences, University of Calgary, Calgary, Alberta T2N1N4, Canada.
Erik SegerdellDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.
DongZhuo WangDepartment of Biological Sciences, University of Calgary, Calgary, Alberta T2N1N4, Canada.
Konrad ThornerDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.
James D WasmuthFaculty of Veterinary Medicine, University of Calgary, Calgary, Alberta T2N1N4, Canada.
Malcolm FisherDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.ORCID 0000-0003-1074-8103
Kamran KarimiDepartment of Biological Sciences, University of Calgary, Calgary, Alberta T2N1N4, Canada.ORCID 0000-0001-5733-9409
Aaron M ZornDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.
Peter D VizeDepartment of Biological Sciences, University of Calgary, Calgary, Alberta T2N1N4, Canada.ORCID 0000-0001-8026-0424

Funding

Xenbase: the Xenopus Model Organism KnowledgebaseP41HD064556 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Aaron M Zorn · 2010 to 2026
$24.9M
Eunice Kennedy Shriver National Institute of Child HealthHuman Development of the National Institutes of Health P41HD064556NICHD NIH HHS P41 HD064556NIH HHS
6 · The paper itself

Abstract

The Xenopus model organism knowledgebase, Xenbase (www.xenbase.org), bridges a wide variety of data types including genomes, anatomy, phenotypes, proteins, diseases and more. The goal of Xenbase is to support Xenopus molecular, cell and developmental biology research, to make these data available to the broader biomedical ecosystem, and accelerate the translation of Xenopus research into knowledge that will improve human health. Connections are made between data through relationships in our core data model and via a series of ontologies that serve as graph-based maps that can be traversed in various dimensions to find connections within our vast corpus of data. Data is input by a team of expert curators applying FAIR data management principles and also via automated pipelines and data processing routines. While our main focus is embryonic development and cell biology, these are often the underlying causes of compromised human health and are therefore invaluable for exploring the medical impacts of DNA sequence variants identified through patient exome or whole genome sequencing. One of the foundational elements in Xenbase with our gene-centric data structure is genomes, and we have recently vastly improved the quality of these core resources for both Xenopus laevis and Xenopus tropicalis. These and an extensive suite of other improvements are described, including updates and upgrades in content types, software and systems.

Indexed as

Databases, GeneticXenopusAnimalsGenomeHumansXenopus laevisanimal modelsdatabaseFAIR datagenomicsknowledgebaseXenopus

Identifiers

PMID41182265
PMCPMC13050207

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.