ArticleJournal of neurotrauma2026
Multimodal Biomarkers of Consciousness in Acute Severe Traumatic Brain Injury.
Article in Journal of neurotrauma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cognitive Motor Dissociation in Disorders of Consciousness: An Individual Participant Data Meta-Analysis.European journal of neurology · 2026Pooled it
- Covert brain complexity in the intensive care unit.Cortex; a journal devoted to the study of the nervous system and behavior · 2026Article
- Updates in Management of Acute Disorders of Consciousness After Traumatic Injury.Brain sciences · 2026Review
- Integrated Blood Biomarker and Neurobehavioural Signatures of Latent Neuroinjury in Experienced Military Breachers Exposed to Repetitive Low-Intensity Blast.International journal of molecular sciences · 2026Article
- Non-invasive neuroregulation techniques applied to patients with consciousness disorders: a narrative review.Frontiers in human neuroscience · 2026Review
- Disorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable.Intensive care medicine · 2026Review
- Prospective validation protocol for artificial intelligence-assisted standardization of Coma Recovery Scale-Revised scores using electroencephalography and clinical data in disorders of consciousness.Frontiers in medicine · 2026Article
- Preservation of anticorrelated brain networks predicts recovery after traumatic brain injury.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Functional fractionation of large-scale brain networks in the human subcortex.bioRxiv : the preprint server for biology · 2025Article
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11 authors.
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Abstract
Predicting outcome for patients with acute severe traumatic brain injury (TBI) is imprecise, relying on neurological examination, structural neuroimaging, and resting-state electroencephalography (EEG) to serve as proxies for brain function. We implemented a multimodal assessment protocol to determine whether detection of consciousness using advanced tools, including standardized behavioral evaluation, advanced EEG, and functional magnetic resonance imaging (fMRI), is associated with functional outcome in patients with acute severe TBI admitted to the intensive care unit (ICU). We tested the association between 6-month Disability Rating Scale (DRS) scores and acute level of consciousness on the Coma Recovery Scale-Revised (CRS-R); responses to active-motor-imagery and passive-language EEG and fMRI; and resting-state fMRI default mode network (DMN) connectivity. We consecutively enrolled 55 patients with acute severe TBI. Six-month outcome was available in 45 (45.2 ± 20.7 years old, 70% male), of whom 10 died, all due to withdrawal of life-sustaining treatment (WLST). All deaths occurred in participants who were not behaviorally following commands. Lower (i.e., better) 6-month DRS scores were observed in participants who were younger (ρ = 0.401; 95% confidence interval [CI: 0.078, 0.649];
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