SynthesisEmerging microbes & infections2025
High case fatality rate of human adenovirus type 7 infections in children: a meta-analysis and phylogenetic study of HAdV-7 epidemics over the past seven decades.
Synthesis in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High pathogenicity of human adenovirus type 55 in adult males: a meta-analysis and phylogenetic study of HAdV-55 epidemics worldwide over the past six decades.Emerging microbes & infections · 2026Pooled it
- First detection of human adenovirus type 7 deletion mutant associated with an outbreak of acute respiratory infection.Virology journal · 2026Article
- CD46 and DSG2 synergistically mediate human adenovirus type 7 infection.Journal of virology · 2026Article
- Antiviral Efficacy of the Traditional Chinese Medicine Mixture Yuanzhixingrenheji Against Human Adenovirus-7 In Vitro, In Vivo, and in a Clinical Retrospective Study.Pathogens (Basel, Switzerland) · 2026Article
- Recent progress in understanding ferroptosis mechanisms in infectious diseases.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Human adenovirus type 7 (HAdV-7) is a significant respiratory pathogen associated with severe infections, particularly among children and military populations. Despite numerous reported outbreaks, comprehensive data on its case fatality rate (CFR) are scarce. We conducted a meta-analysis of 305 PubMed articles (1954-2023) and phylogenetic analyses of 313 HAdV-7 genomes and capsid protein gene sequences available in GenBank, and estimated temporal evolutionary dynamics using Bayesian methods. Our analysis identified 16,100 HAdV-7 cases with 388 deaths (CFR: 2.41%), of which 87.63% (340) occurred in children. Cases were reported globally, except in Antarctica; Asia had the highest number (10,827), followed by North America and Europe. Mainland China recorded the most fatalities (150), followed by the United States and South Korea (53 and 39, respectively). HAdV-7 primarily infected the respiratory system (11,617 cases, 72.16%), followed by the gastrointestinal systems (957 cases, 5.94%), with limited central nervous system involvement (126 cases, 0.78%). A literature search on HAdV-related fatalities across six HAdV species identified 667 deaths, of which HAdV-7 was the dominate type (262 cases, 39.28%). Phylogenetic analysis revealed three variants (7V, 7E1, 7E2). The 7E2 variant, dominant after 2005, was associated with more deaths (91 cases, 67.91%) than 7E1 variant (43 cases, 32.09%). Bayesian analysis estimated a substitution rate of 3.89 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.