ArticleJournal of the American Heart Association2025
Dual Contrast-Enhanced Microcomputed Tomography Uncovers Leaflet-Dependent Patterns of Macrocalcification, Fibrous Extracellular Matrix Remodeling, and Adipocyte Degeneration in Calcific Aortic Stenosis.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
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Abstract
backgroundClinical imaging studies of calcific aortic stenosis have suggested interleaflet pathological differences in patients. In this cross-sectional study, we sought to investigate interleaflet differences in calcification, fibrous extracellular matrix remodeling, and adipocyte degeneration in explanted human aortic valves.
methodsDiseased (n=45) and control (n=39) tricuspid aortic valve leaflets obtained from patients with aortic stenosis and normal aortic valves on echocardiography were assessed for calcification, fibrous extracellular matrix remodeling, and adipocyte degeneration using contrast-enhanced microcomputed tomography in conjunction with scanning and transmission electron microscopy, with interleaflet differences analyzed by fractional response regression.
resultsIn diseased leaflets, the calcification volume fraction was significantly greater in the noncoronary cusp than the left coronary cusp (LCC; β=0.313 [95% CI, 0.048-0.579],
conclusionsValvular calcification diverges from fibrous extracellular matrix remodeling but converges with adipocyte degeneration in terms of preferential impact on the noncoronary cusp versus, in particular, the LCC. Future mechanistic studies to elucidate the intimate relationship between adipocyte degeneration and valvular calcification may provide opportunities for further therapeutic development.
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