Evidence map›Paper›PMID 41181911›Full record

ArticleCNS spectrums2025

Moving beyond symptom subtypes: testing a common dimension of lifetime OCD symptoms.

Abel S Mathew, Sarah L Garnaat, David R Strong, Nicole C R McLaughlin, Kathleen D Askland, O Joseph Bienvenu, Janice Krasnow, Marco A Grados, Bernadette Cullen, Fernando S Goes and 11 more

Abstract read
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In one paragraph

Article in CNS spectrums, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Abel S MathewDepartment of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI, USA.ORCID 0009-0004-3681-1136
Sarah L GarnaatDepartment of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI, USA.
David R StrongDepartment of Family Medicine and Public Health, University of California San Diego, San Diego, CA, USA.
Nicole C R McLaughlinDepartment of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI, USA.
Kathleen D AsklandAskland Medicine Professional Corporation & Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
O Joseph BienvenuDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Janice KrasnowDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Marco A GradosDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Bernadette CullenDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Steven RasmussenDepartment of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI, USA.
James A KnowlesDepartment of Genetics, Rutgers University-New Brunswick, New Brunswick, NJ, USA.
James T McCrackenDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, School of Medicine, Los Angeles, CA, USA.
John PiacentiniDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, School of Medicine, Los Angeles, CA, USA.
Daniel GellerDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Evelyn StewartDepartment of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, BC, USA.
Mark A RiddleDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Paul NestadtDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gerald NestadtDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jack SamuelsDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Benjamin D GreenbergDepartment of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionObsessive-compulsive disorder (OCD) is a neuropsychiatric disorder characterized by recurrent intrusive thoughts and ritualized behaviors, often aimed at reducing distress. OCD is heterogeneous in its presentation and many patients with OCD experience a variety of different symptoms throughout their course of illness. Efforts to understand symptom domains in OCD have typically identified three to five symptom domains, such as the domains of doubt/checking, contamination, superstitions/rituals, symmetry/hoarding, and taboo thoughts. Recent studies in the genetics of OCD have suggested a common OCD dimension may provide additional information above and beyond the previously identified symptom domains. Thus, we sought to test a hierarchical model of lifetime OCD symptoms and evaluate the utility of the inclusion of a common OCD dimension.

methodsParticipants included 999 individuals participating in the OCD Collaborative Genetics Study (OCGS) and an additional 2363 individuals participating in the OCD Genetic Association Study (OCGAS). We evaluated unidimensional, 5-factor, and hierarchical models of lifetime OCD symptom presentation using confirmatory factor analysis.

resultsResults suggested that the hierarchical model best fit the data. Further evaluation of these models using a Bayesian testlet response model showed that lifetime presence of specific OCD symptoms was differentially associated with lifetime OCD severity. Moreover, symptoms associated with greater lifetime severity were generally reported less frequently than symptoms present at lower levels of lifetime severity. Implications of these findings and future directions are discussed.

Indexed as

Obsessive-Compulsive DisorderAdultFactor Analysis, StatisticalFemaleHumansMaleMiddle AgedYoung Adultitem response theorylifetime OCD symptomsObsessive-compulsive disorderOCDYale-Brown Obessive Compulsive ScaleY-BOCS

Identifiers

PMID41181911
PMCPMC13064779

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.