Evidence map›Paper›PMID 41181904›Full record

ArticleANZ journal of surgery2026

Selective Pectoralis Muscle Denervation Reduces Capsular Contracture in Sub-Pectoral Breast Reconstruction. Long-Term Retrospective Case- Control Study.

Marco Bernini, Federico Spolveri, Margherita Serra, Silvia Sordi, Cinzia Tommasi, Lorenzo Orzalesi, Lorenzo Tofani, Chiara Bellini, Diego De Benedetto, Jacopo Nori Cucchiari and 5 more

Abstract read
In one paragraph

Article in ANZ journal of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marco BerniniBreast Surgery, Breast Unit, Breast Surgery Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Federico SpolveriBreast Surgery, Breast Unit, San Jacopo Hospital, Pistoia, Italy.
Margherita SerraBreast Surgery, Breast Unit, Breast Surgery Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Silvia SordiDepartment of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Cinzia TommasiBreast Surgery, Breast Unit, Oncology Department, Careggi University Hospital, Florence, Italy.
Lorenzo OrzalesiDepartment of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Lorenzo TofaniDepartment of Statistic, Computer Science, Applications, University of Florence, Florence, Italy.
Chiara BelliniDiagnostic Senology Unit, Careggi University Hospital, Florence, Italy.
Diego De BenedettoDiagnostic Senology Unit, Careggi University Hospital, Florence, Italy.
Jacopo Nori CucchiariDiagnostic Senology Unit, Careggi University Hospital, Florence, Italy.
Luca VisaniRadiation Oncology, Breast Unit, Oncology Department, Careggi University Hospital, Florence, Italy.
Carlotta BecheriniRadiation Oncology, Breast Unit, Oncology Department, Careggi University Hospital, Florence, Italy.
Viola SalvestriniRadiation Oncology, Breast Unit, Oncology Department, Careggi University Hospital, Florence, Italy.
Lorenzo LiviRadiation Oncology, Breast Unit, Oncology Department, Careggi University Hospital, Florence, Italy.
Icro MeattiniRadiation Oncology, Breast Unit, Oncology Department, Careggi University Hospital, Florence, Italy.

Funding

Ministero della Salute RC-2025-2796965
6 · The paper itself

Abstract

backgroundImplant-based breast reconstruction (IBBR) is the most common method of breast reconstruction globally. Although the traditional approach places implants in a retropectoral position, pre-pectoral reconstruction has recently gained popularity due to its improved aesthetic outcomes and lower capsular contracture (CC) rates. However, not all patients are ideal candidates for prepectoral IBBR, making the retropectoral technique still a valuable option. Capsular contracture is a common complication of IBBR, causing discomfort, pain, poor cosmetic results, and often necessitating revision surgery, particularly in retropectoral cases. Selective denervation of the pectoralis major muscle (PMM) in retropectoral IBBR is a novel technique to reduce these complications. MATERIAL AND

methodsWe selected a group of denervated retro-pec IBBR patients and compared them to non-denervated patients. In a previous study, we analyzed the subjective opinions on the reconstruction outcomes using the BREAST-Q postoperative questionnaire. At the same time, we compared retrospectivally the same groups, with a minimum 24-month follow-up, from an objective perspective, evaluating CC rates by Baker scale and possible implant malrotation through outpatient clinic visits performed by three independent breast cancer professionals.

resultsThe overall mean follow-up was 3.33 (±0.47) years, and the CC rate was significantly lower in Group 1, even adjusting for the propensity score.

conclusionsPMM selective denervation has gained statistical appreciation by women and significantly reduced the CC rate from an objective evaluation in the setting of retro-pectoral IBBR in our series.

Indexed as

Breast ImplantationBreast NeoplasmsDenervationImplant Capsular ContractureMammaplastyMuscle DenervationPectoralis MusclesAdultBreast ImplantsCase-Control StudiesFemaleFollow-Up StudiesHumansMiddle AgedRetrospective StudiesTreatment Outcomeanimation deformitycapsular contractureimplant‐based breast reconstructionimplant malrotationpectoralis major muscle denervationpre‐pectoral breast reconstructionretro‐pectoral breast reconstruction

Identifiers

PMID41181904
PMCPMC12953744

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.