ArticleEClinicalMedicine2025
Adherence to adjuvant endocrine therapy including GnRH-analogues and survival: a population-based cohort study.
Article in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Association of mobile application information on multidisciplinary therapy and treatment compliance in early-stage breast cancer: A prospective multicenter randomized phase III study.Breast (Edinburgh, Scotland) · 2026Trial
- Emerging Approaches in Breast Cancer: From Molecular Mechanisms to Diagnosis and Therapeutic Strategies.Oncology research · 2026Review
- Breaking the silence and building strength; rethinking menopause care through exercise and cultural insight.Frontiers in global women's health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Adjuvant endocrine therapy (AET) combining gonadotropin-releasing hormone analogues (GnRHa) with tamoxifen (TAM) or aromatase inhibitors (AI) improves survival in premenopausal women with breast cancer compared to TAM and is increasingly prescribed. However, there are concerns regarding adherence. Methods: Through linkages to Swedish national healthcare registers, we conducted a population-based cohort study including women diagnosed with early, invasive, estrogen receptor-positive breast cancer, January 2007 to December 2020, in the Stockholm-Gotland region, Sweden, with at least one dispensation of oral AET (n = 16,468). Follow-up ended January 14, 2022.AET was categorized based on the first dispensed oral AET (AI or TAM) and if GnRHa had been dispensed within three months of this, into the respective combination group (GnRHa + TAM or GnRHa + AI). Adherence was defined as a medication possession ratio ≥80% over five years for oral AET and two years for GnRHa, or the shortest interval from first dispensation to recurrence, contralateral breast cancer, death, emigration, or end of follow-up, if they preceded five and two years, respectively.To study the association of type of AET and non-adherence, odds ratios (OR) were calculated using logistic regression. The association between non-adherence and invasive breast cancer-free survival (IBCFS) was studied with landmark analysis, calculating hazard ratios (HR) using the Cox proportional hazards model and flexible parametric modeling. Findings: Adherence was 86% to AI, 79% to TAM, 75% to both TAM + GnRHa, and AI + GnRHa (p < 0.001). Adjusted OR for non-adherence was 1.40 (95% confidence interval (CI) 1.27-1.55) for TAM, 2.73 (95% CI 2.19-3.40) for TAM + GnRHa, and 2.92 (95% CI 2.24-3.79) for AI + GnRHa, respectively, compared to AI. Adjusted HR of IBCFS were 1.43 (95% CI 1.26-1.64) and 1.19 (95% CI 1.04-1.35) at one- and five-year landmark analysis, respectively, comparing non-adherent to adherent groups. Interpretation: Adherence was lower to combination regimens than to single AET, and non-adherence was associated with poorer survival. Future prospective studies are warranted to validate these findings. Funding: This work was supported by grants to TF from the Swedish Cancer Society (Cancerfonden) (grant no. 21 1800Pj), Vetenskapsrådet (grant no. 2021-03061), Cancerföreningen i Stockholm (grant no. 234073), and Region Stockholm (Stockholms Läns Landsting) (grant no. FoUI-974936).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.