Evidence map›Paper›PMID 41181771›Full record

ArticleCureus2025

Bowenoid Actinic Keratosis in a Patient Receiving Abatacept for Rheumatoid Arthritis: A Case Report.

Maya Kaga, Hirofumi Amano, Takayuki Kon, Kanako Ogura

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maya KagaDepartment of Dermatology, Juntendo University Nerima Hospital, Tokyo, JPN.
Hirofumi AmanoDepartment of Rheumatology and Internal Medicine, Juntendo University Nerima Hospital, Tokyo, JPN.
Takayuki KonDepartment of Rheumatology and Internal Medicine, Juntendo University Nerima Hospital, Tokyo, JPN.
Kanako OguraDepartment of Pathology and Laboratory Medicine, Juntendo University Nerima Hospital, Tokyo, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We experienced a case of Bowenoid actinic keratosis on the left wrist joint in a patient receiving abatacept for rheumatoid arthritis. Simple treatment with imiquimod, initiated with the continuous use of abatacept, did not improve the lesion. Topical imiquimod successfully cured the lesion only after abatacept discontinuation in the patient. Our case suggests that abatacept has depleted the production of tumor necrosis factor-α by macrophages upon contact with imiquimod, which is a toll-like receptor 7 ligand.

Indexed as

abataceptactinic keratosisbowenoid actinic keratosisimiquimodrheumatoid arthritistoll-like receptors

Identifiers

PMID41181771
PMCPMC12578603

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.