ReviewFrontiers in cell and developmental biology2025
Microglia and programmed cell death in spinal cord injury: beyond apoptosis.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- TrxR Inhibition and Nrf2-FOXO3 Modulation by Repurposed Drugs: A Redox Strategy to Reverse Cancer Multidrug Resistance.Drug development research · 2026Review
- "Membrane-Guided" Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Uric Acid Released from Poly (Lactic-co-Glycolic Acid) Nanoparticles Mitigates Glutamate-Induced Excitotoxicity of Spinal Cord Neurons.ASN neuro · 2026Article
- Integrative single-cell and bulk transcriptomic analyses identify a microglia-associated NAGLU signature linked to disulfidptosis-associated transcriptional patterns after spinal cord injury.Frontiers in immunology · 2026Article
- Blood-spinal cord barrier disruption after spinal cord injury: a time-dependent mechanistic review.Frontiers in cellular neuroscience · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal cord injury (SCI) triggers a multifaceted cascade of cellular and molecular events that profoundly influence the extent of secondary damage. Central to this process, microglia-the innate immune cells of the central nervous system-display a range of programmed cell death pathways that have significant implications for injury outcomes. This article mainly focuses on three key programmed cell death modalities that have emerged in SCI: ferroptosis, autophagy, and pyroptosis. Ferroptosis, characterized by iron-dependent lipid peroxidation, autophagy, which can serve dual roles in cell survival and death, and pyroptosis, an inflammatory form of cell death, contribute uniquely to the progression and resolution of post-injury neuroinflammation. We examine the underlying molecular mechanisms, the regulatory networks that integrate these pathways, and how their dysregulation may exacerbate tissue damage. Moreover, potential therapeutic strategies to modulate these specific cell death processes are discussed, offering promising avenues for reducing secondary damage and enhancing recovery in patients with SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.