ArticleWorld journal of cardiology2025
Efficacy and safety of interatrial shunt treatment for heart failure: A systematic review and meta-analysis.
Article in World journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
backgroundHeart failure (HF), especially in patients with preserved ejection fraction and mid-range ejection fraction, remains a significant global health burden. Interatrial shunt devices (IASDs), which allow blood flow from the left to the right atrium, offer a novel treatment approach by reducing left atrial pressure and alleviating symptoms.
aimTo evaluate the efficacy and safety of IASDs in patients with HF through a systematic review and meta-analysis.
methodsWe performed a systematic review and meta-analysis following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, analyzing studies up to April 2025. Randomized controlled trials and observational studies comparing interatrial shunt therapy with control groups were included. Data on clinical outcomes were analyzed using Review Manager software.
resultsNine studies involving 1689 patients were included. IASDs significantly improved cardiac output [mean difference (MD): 0.72, 95%CI: 0.13-1.32,
conclusionIASDs offer significant short-term improvements in cardiac output, RAP, and exercise capacity in HF patients. However, long-term safety concerns, particularly regarding mortality, necessitate further research and careful patient selection.
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