Evidence map›Paper›PMID 41181629›Full record

ArticleOncology letters2025

Submandibular adenoid cystic carcinoma presenting with liver metastasis as the initial symptom: A case report.

Tianyi Li, Tingyao Ma, Yue Zhao, Shujing Zhang, Guoliang Yang, Xuelian Wang, Xudong Wang, Mingzhu Wang, Xi Zhao, Hongfei Liu and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tianyi LiDepartment of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
Tingyao MaDepartment of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
Yue ZhaoDepartment of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
Shujing ZhangDepartment of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
Guoliang YangDepartment of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
Xuelian WangDepartment of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
Xudong WangDepartment of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
Mingzhu WangDepartment of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
Xi ZhaoDepartment of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
Hongfei LiuDepartment of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
Jun WuDepartment of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
Xiaoli ZhaoDepartment of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.
Xiaohong ChenDepartment of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenoid cystic carcinoma (ACC) is a rare and aggressive malignancy characterized by a high incidence of distant metastasis. However, cases of ACC with liver and lymph node metastases are rarely reported and lack a standardized treatment consensus. The present report describes the case of a submandibular gland ACC with liver metastasis manifesting as the initial symptom. PET/CT revealed masses in the left submandibular gland and the liver. The patient underwent right tri-lobe hepatectomy and resection of the submandibular gland tumor. Histological examination of the tumor revealed a cribriform type with both lymphovascular invasion and perineural invasion. New lymph node metastases were observed 21 months after surgery of the submandibular gland tumor, and no further treatment was administered to date. The patient has survived for 28 months since the diagnosis of liver metastasis and currently exhibits stable vital signs. In conclusion, the present case illustrates a rare, high-risk variant of rapidly progressing submandibular gland ACC, with liver metastasis serving as the initial presenting symptom. A multidisciplinary approach is essential for the effective management of complex metastatic ACC.

Indexed as

adenoid cystic carcinomahead and neck cancerliver metastasissubmandibular gland

Identifiers

PMID41181629
PMCPMC12572763

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