ArticleFrontiers in pharmacology2025
Alkaloid-driven multi-target synergy of
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Methods: UPLC-QTOF-MS was used for chemical profiling. Network pharmacology predicted putative targets, validated by GEO transcriptomic datasets. Key alkaloid-target interactions were examined by molecular docking and 100-ns MD simulations. Results: Thirty-eight constituents were identified, including 18 alkaloids. Five core targets (EGFR, JAK1, JAK2, PTPN11, SRD5A1) were pinpointed by network-clinical integration. Several alkaloids ranked among the top compounds by network degree, exhibited strong predicted binding affinities (ΔG ≤ -7 kcal/mol), and formed stable complexes in molecular dynamics simulations. Functionally, TWP reduced viability, induced apoptosis, and de-phosphorylated EGFR, JAK1/2, and PTPN11, downregulated SRD5A1, and suppressed PI3K-AKT, JAK-STAT, and ERK-MAPK signaling. Conclusion: Our findings suggest that alkaloids in TWP may exert multi-target synergy to disrupt key survival pathways driving cisplatin resistance in ovarian cancer. These mechanistic insights not only rationalize its observed anti-tumor activity but also support its potential clinical repurposing from an approved anti-inflammatory drug to an oncology therapeutic.
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