Evidence map›Paper›PMID 41181574›Full record

ArticleAdvanced functional materials2025

The Synergy of Artificial Intelligence and 3D Bioprinting: Unlocking New Frontiers in Precision and Tissue Fabrication.

Joao Vitor Silva Robazzi, I Deniz Derman, Deepak Gupta, Logan Haugh, Yogendra Pratap Singh, Vaibhav Pal, Yasar Ozer Yilmaz, Suihong Liu, Andre Luis Dias, Rogerio Andrade Flauzino and 1 more

Abstract read
In one paragraph

Article in Advanced functional materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joao Vitor Silva RobazziEngineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, USA.
I Deniz DermanEngineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, USA.
Deepak GuptaEngineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, USA.
Logan HaughBiomedical Engineering Department, Penn State University, University Park, PA, 16802, USA.
Yogendra Pratap SinghEngineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, USA.
Vaibhav PalEngineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, USA.
Yasar Ozer YilmazEngineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, USA.
Suihong LiuEngineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, USA.
Andre Luis DiasDepartment of Electrical and Computer Engineering, Federal Institute of Sao Paulo, Sertaozinho, Brazil.
Rogerio Andrade FlauzinoDepartment of Electrical and Computer Engineering, University of Sao Paulo, Sao Carlos, Brazil.
Ibrahim Tarik OzbolatEngineering Science and Mechanics Department, Penn State University, University Park, PA, 16802, USA.

Funding

Technology Development Project - Increasing the complexity of ex vivo human airway models for studying immune response to viral infectionU19AI142733 · NIAID · JACKSON LABORATORY · PI Anna Karolina Palucka · 2019 to 2026
$23.1M
Intraoperative bioprinting of composite tissues with zonal stratification for craniomaxillofacial reconstructionR01DE028614 · NIDCR · PENNSYLVANIA STATE UNIVERSITY, THE · PI OZBOLAT, IBRAHIM · 2020 to 2024
$2.8M
High-throughput Spheroid Bioprinting Technology for Scalable Fabrication of TissuesR01EB034566 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI Ibrahim Ozbolat · 2023 to 2026
$2.2M
3D Printing of Air: An Intangible Ink for Fabrication of Vascularized TissuesR01EB036245 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI Ibrahim Ozbolat, DINO J RAVNIC · 2024 to 2026
$1.7M
NIAID NIH HHS U19 AI142733NIBIB NIH HHS R01 EB034566NIBIB NIH HHS R01 EB036245NIDCR NIH HHS R01 DE028614
6 · The paper itself

Abstract

This Review examines the transformative role of artificial intelligence (AI) in 3D bioprinting, focusing on how advanced AI technologies enhance its precision, functionality, and scalability. AI, through branches, such as machine learning (ML), computer vision (CV), robotics, natural language processing and expert systems, provides critical improvements in real-time process monitoring, error correction, and optimization of bioprinting parameters. The integration of AI enables automated quality control and predictive maintenance, improving bioprinting outcomes by increasing cell viability and structural fidelity, and reducing the amount of bioink wasted. Specifically, ML algorithms are employed to predict optimal bioprinting conditions and streamline the bioprinting workflow, while deep learning enhances the ability to process complex datasets for precision tissue biofabrication. Furthermore, AI-powered robotics and CV systems ensure accurate bioink placement and facilitate the construction of complex tissues. Despite the remarkable progress, challenges remain, particularly in the areas of process monitoring, quality control, and the scalability of bioprinting systems. This Review also aims to guide scientists, engineers, and healthcare providers in understanding the complexities and potential of AI-enhanced bioprinting, fostering a deeper appreciation of its role in the future of regenerative medicine and personalized healthcare.

Indexed as

3d bioprintingartificial intelligencecomputer visionexpert systemsmachine learningnatural language processingrobotics

Identifiers

PMID41181574
PMCPMC12577758

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.