Evidence map›Paper›PMID 41181537›Full record

ArticleWorld journal of gastrointestinal endoscopy2025

Effect of family history on detection of adenomas and sessile serrated lesions in individuals aged 40s.

Osamu Toyoshima, Toshihiro Nishizawa, Hiroki Asano, Mari Mizutani, Takeshi Uozumi, Ai Fujimoto, Masaya Sano, Shuntaro Yoshida, Keisuke Hata, Hirotoshi Ebinuma

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In one paragraph

Article in World journal of gastrointestinal endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Osamu ToyoshimaDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan. t@ichou.com.
Toshihiro NishizawaDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan.
Hiroki AsanoDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan.
Mari MizutaniDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan.
Takeshi UozumiDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan.
Ai FujimotoDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan.
Masaya SanoDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan.
Shuntaro YoshidaDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan.
Keisuke HataDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo 157-0066, Japan.
Hirotoshi EbinumaDepartment of Gastroenterology and Hepatology, International University of Health and Welfare Narita Hospital, Narita 286-8520, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccording to the guidelines in the United States, individuals with a family history of colorectal cancer should be screened at the age of 40 years. Data on the prevalence of adenomas and sessile serrated lesions (SSLs) in individuals aged 40-49 years in Japan are lacking.

aimTo investigate the effect of family history on the detection of adenomas and SSLs during colonoscopy in Japan.

methodsThis retrospective, single-center cohort study included individuals aged 40-79 years who underwent colonoscopy by expert endoscopists with an adenoma detection rate (ADR) ≥ 40% between 2021 and 2024. The ADR and adenoma plus SSL detection rate (ASDR) were investigated according to age. Multivariable analyses were performed to examine the effects of first-degree family history of colorectal cancer, fecal immunochemical test, and sex on the ADR and ASDR for each age group. A binomial logistic regression model was used.

resultsIn 10248 participants, the overall ADR and ASDR were 53.6% and 59.1%, respectively. The ADR and ASDR increased with age. Among 2317 participants aged 40-49 years, the presence of a family history significantly increased the ADR (47.6%

conclusionParticipants with a family history exhibited significantly elevated ADR (47.6%) and ASDR (58.0%), in their 40s. Individuals with a family history should initiate colonoscopy at 40 years old.

Indexed as

AgeColonoscopyColorectal neoplasiaFamily historySessile serrated lesions

Identifiers

PMID41181537
PMCPMC12576680

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.