ArticleAnnals of medicine and surgery (2012)2025
Long-term efficacy and safety of endovascular thrombectomy for acute ischemic stroke with large vessel occlusion: a systematic review and meta-analysis.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Endovascular thrombectomy (EVT) improves functional outcomes at 90 days in patients with acute ischemic stroke (AIS) with large vessel occlusion (LVO). However, its long-term efficacy and safety beyond 90 days remain unclear. Objective: We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of EVT plus best medical treatment (BMT) versus BMT alone beyond 90 days in patients with AIS and LVO. Methods: PubMed, Embase, and Cochrane Central databases were searched to identify randomized controlled trials (RCTs) comparing EVT plus BMT versus BMT alone in AIS patients with LVO. Primary outcomes included functional independence (mRS ≤2), independent ambulation (mRS ≤3), death or dependency (mRS 4-6), and all-cause mortality beyond 90 days. We applied a random-effects model and pooled risk ratios (RRs) along with 95% confidence intervals (CIs) using the Cochrane RoB2 tool for assessing risk of bias in randomized trials. Results: Seven RCTs with 2358 patients (56% males) were included. The mean age of the patients was 69.5 years and mean follow-up duration was 1.2 years. The results showed that EVT combined with BMT improved functional independence (mRS ≤2) (RR 2.08, CI: 1.55-2.80; Conclusion: EVT combined with BMT significantly improves long-term functional outcomes and quality of life and reduces mortality in AIS patients with LVO compared to BMT alone.
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