ReviewAnnals of medicine and surgery (2012)2025
Long-term neurodevelopmental outcomes in children with hypoplastic left heart syndrome.
Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect requiring complex surgical interventions, including the Norwood, Glenn, and Fontan procedures. This narrative review aims to explore the long-term neurodevelopmental outcomes of children with HLHS following surgical palliation with potential risk factors. Objectives: This review synthesizes current evidence on long-term ND outcomes in children with HLHS after surgical palliation and identifies key risk factors, assessment tools, and emerging neuroprotective strategies. Methods: A comprehensive literature review was conducted, focusing on the interplay of altered fetal circulation, impaired cerebral oxygenation, and extensive medical interventions on neurodevelopment. We conducted literature search of full-text, peer-reviewed English articles published between 2000 and 2024 using PubMed, Scopus, and Google Scholar with the terms "hypoplastic left heart syndrome," "surgical palliation," "neurodevelopmental outcomes," and "children." Results: Evidence indicates that children with HLHS face significant risks for cognitive, motor, behavioral, and adaptive impairments. Assessment tools such as the Bayley Scales of Infant and Toddler Development, MRI, and EEG are essential for early detection and ongoing monitoring. Discussion: A multidisciplinary approach involving pediatric cardiology, neurology, and developmental therapy is crucial for managing HLHS and addressing neurodevelopmental issues. Early intervention can improve outcomes, guided by diagnostic tools like MRI, EEG, and the Bayley Scales. There is a need for more research on neuroprotective strategies and perioperative management to reduce brain injury and enhance long-term developmental outcomes in children with HLHS. Conclusion: Children with HLHS face significant ND challenges due to a complex interplay of physiological and medical factors. A multidisciplinary approach with early intervention is critical. Emerging strategies, such as maternal hyperoxygenation, merit further investigation regarding their feasibility, cost, and ethical considerations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.