ReviewJournal of inflammation research2025
Mechanisms Underlying Lichen Planus in Association with Biologic Therapy.
Review in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cutaneous reactions, including lichen planus (LP) and related lichenoid eruptions have been increasingly reported in association with biologic therapies including immune checkpoint inhibitors and tumor necrosis factor-α inhibitors. Since the immunologic mechanisms underlying biologic-associated LP remain unclear, we aimed to summarize current evidence on biologic-induced LP, outline implicated drug classes, and propose mechanistic models. We conducted a comprehensive systematic analysis of PubMed literature, reviewing 145 publications that identified 157 cases of biologic-associated LP and proposed several overlapping immunological mechanisms, including cytokine imbalances, T cell immune pathway shifts, antigen unmasking, keratinocyte apoptosis dysregulation, and host susceptibility. Management of biologic-associate LP includes withdrawal of the offending biologic and adjunctive treatment. Further research is needed to clarify mechanistic pathways, define incidence, and identify predictive biomarkers that may guide risk stratification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.