ArticleFrontiers in cellular and infection microbiology2025
Evaluating lymphocyte change rate and lactate as predictors of prognosis in critical COVID-19 patients in the intensive care unit.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Studies have shown that lymphocyte counts and lactate (LAC) levels have a certain relationship with the prognosis of COVID-19 patients. In the present study, we aimed to determine the predictive effects of new indicator lymphocyte change rate and LAC on the prognosis of COVID-19 patients. Methods: In the present study, we retrospectively analyzed the clinical data of 137 adult patients (≥ 18 years old) diagnosed with the COVID-19 Omicron variant, who were admitted to the comprehensive, respiratory, or infection ICU of our hospital, between November 2022 and February 2023. Cox regression and causal mediation analyses were used to evaluate the relationship between the clinical test data and patient prognosis. Results: A total of 137 patients with COVID-19 were included in the present study, 77.40% of whom were male, with an average age of 73 years and an overall mortality rate of 51.8%. Multifactorial logistic regression analysis showed that LAC (odds ratio [OR], 0.05; 95% confidence interval [CI], 0-0.1; Conclusion: In summary, lymphocyte change rate combined with LAC had the greatest predictive value for COVID-19 ICU patient prognosis, while respiratory-related indicators had no significant relationship with prognosis, so we suggest the increase of LAC in COVID-19 patients may be caused by microcirculatory disturbances.
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