ArticleFrontiers in cellular and infection microbiology2025
Clinical features of influenza-associated pulmonary aspergillosis: a retrospective multicenter cohort study.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Clinical characteristics, diagnosis and prognosis of Talaromyces marneffei pneumonia in kidney transplant recipients: a retrospective study.BMC infectious diseases · 2026Article
- Evaluation of Large Language Models in Infectious Disease Decision-Making: From Examination to Clinical Practice.Infection and drug resistance · 2026Article
- Machine learning for early screening of influenza A-associated invasive pulmonary aspergillosis in hospitalized patients: a real-world study.Frontiers in cellular and infection microbiology · 2026Article
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Authors and funding
7 authors.
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Abstract
Rationale: Influenza-associated pulmonary aspergillosis (IAPA) is a great clinical challenge, which has high morbidity and mortality in severe influenza infections. Unlike invasive pulmonary aspergillosis (IPA), IAPA often occurs in immunocompetent hosts. That IAPA lacks of specific manifestations makes it difficult to diagnose and causes a high mortality rate, which is becoming challenges toclinicians. Exploring the clinical characteristics of IAPA in depth is of great significance for guiding clinical practice. Objectives: To determine the clinical features of IAPA in order to support appropriate clinical management of this public health threat. Methods: A retrospective multicenter cohort study was conducted. The clinical characteristics, risk factors, diagnostic methods, treatment, and prognosis data of the participants were analyzed. Results: Diabetes and lymphopenia were important risk factors for IAPA. Pulmonary imaging showed that IAPA patients had more nodular lesions in the lungs, and a higher proportion of them were accompanied by cavitary lesions. The galactomannan (GM) test in bronchoalveolar lavage fluid (BALF) showed high sensitivity and specificity for diagnosing IPA. The positive rate of Conclusions: Diabetes and lymphopenia were important risk factors for IAPA. The comprehensive application of serum and BALF GM, M-ROSE and tNGS could significantly improve the detection rate of
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