ArticleJournal of anaesthesiology, clinical pharmacology
Comparing the prophylactic effect of ondansetron versus ephedrine on hemodynamic instability caused by spinal anesthesia for cesarean section.
Article in Journal of anaesthesiology, clinical pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Background and Aims: This study aimed to compare the prophylactic effect of intravenous ondansetron versus ephedrine on hypotension related to spinal anesthesia of cesarean section. The primary outcome was the incidence of maternal hypotension; secondary outcomes were the incidence of nausea and vomiting, the number of vasopressors required, and surgeon satisfaction. Material and Methods: This randomized, double-blind clinical trial study included 120 parturients with ASA physical status I or II who were eligible for elective cesarean section. They were randomly assigned to two groups: receiving ephedrine (10 mg in 10 mL normal saline 0.9% IV) and ondansetron (8 mg in 10 mL normal saline 0.9% IV). The patients were monitored for changes in hemodynamic parameters during surgery and recovery. Results: Among 120 parturients included in this clinical trial, the incidence of hypotension (20% decrease in systolic blood pressure) was significantly lower in the ephedrine group (21.7%) than in the ondansetron group (60%) ( Conclusions: We found that 10 mg IV ephedrine has a significantly greater prophylactic effect than 8 mg IV ondansetron on spinal-induced hypotension during elective cesarean section.
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