ArticleIranian journal of parasitology
Evaluation of Benzimidazole Resistance in Equine Cyathostomins in the Kermanshah Province of Iran Using Coprological Analysis and Allele-Specific PCR.
Article in Iranian journal of parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Molecular Identification and Benzimidazole Resistance Analysis of Cyathostomins in Chinese Grazing Horses.Veterinary sciences · 2026Article
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6 authors.
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Abstract
Background: Resistance to benzimidazole (BZ) by cyathostomin nematodes has become a major threat to equine health around the world. We aimed to evaluate the efficacy of BZ drugs against small strongyle nematodes in horses of western Iran using coprological and molecular examination. Methods: Faecal egg count reduction tests were performed on 398 horses kept in 16 stables in western Iran (Kermanshah Province), to detect benzimidazole resistance in small strongyle nematodes. Allele-specific PCR was used to identify the F200Y (TAC/TTC) SNP in the beta-tubulin gene codon in cyathostomin larvae. Results: There was a 96.1%-98.3% (90% CI) reduction in faecal egg counts following mebendazole treatment and a 96.6% - 98.7% (90% CI) reduction in faecal egg counts following fenbendazole treatment. The allele-specific PCR showed BZ-susceptible homozygote genotypes in all examined samples (Two pools of 10 to 50 L Conclusion: Benzimidazole resistance in equine small strongyles has been reported globally, and the results of the present study were unexpected. The probable reasons for the slow development of BZ-resistance are climatic conditions in the country that have significant negative effects on the ability of free stages of the resistant strongyle nematode to survive and develop.
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