ArticleFrontiers in immunology2025
Integrating bioinformatics and molecular experiments to reveal the critical role of the cellular energy metabolism-related marker PLA2G1B in COPD epithelial cells.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Unfolding Immune Dysregulation in COPD: Identification of a Three-Gene Signature and Functional Validation ofInternational journal of molecular sciences · 2026Article
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9 authors.
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Abstract
Background: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by small airway lesions and persistent airflow limitation. Recent studies have highlighted impaired cellular energy metabolism (CEM) in COPD, although the underlying mechanisms remain incompletely understood. Material and methods: This research identified cell energy metabolism-related differentially expressed genes (CEM-DEGs) by collecting CEM-associated signatures from multiple public databases and integrating these markers with data from the GEO database. Subsequently, five machine learning algorithms-Boruta, Xgboost, GBM, SVM-RFE, and LASSO-were employed to screen for key variables. Gene Set Enrichment Analysis (GSEA) and immune infiltration analysis were then performed on these key CEM-DEGs. Finally, the results of the bioinformatics analysis were verified by Results: Bioinformatic analysis identified six critical markers ( Conclusions: This study identified six CEM-related biomarkers (
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