ArticleFrontiers in immunology2025
Exploring the carcinogenic potential of bisphenol A in lung adenocarcinoma: molecular mechanisms, key gene insights, and immune microenvironment impacts.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Tumor microenvironment-mediated resistance to immune checkpoint inhibitors in non-small cell lung cancer: Mechanisms, combination strategies and clinical perspectives (Review).Molecular and clinical oncology · 2026Review
- Combination of lonidamine with devimistat induces synergistic antitumor effects in lung cancer via multifaceted disruption of cellular energy metabolism.Oncology reports · 2026Article
- Association between the presence of EGFR or ALK mutations and the location of primary non-small cell lung cancer, as well as metabolic activity observed onOncology letters · 2026Article
- A network toxicology and machine learning approach to uncover the molecular machinery of bisphenol A-induced colorectal cancer.Scientific reports · 2026Article
- Phenolic Endocrine-Disrupting Chemical Exposure and Systemic Biomarker Variability in Patients with Lung Cancer.Medicina (Kaunas, Lithuania) · 2026Article
- Immune network remodeling driven by ferroptosis: Bidirectional interaction mechanisms among multiple immune cells in the lung cancer immune microenvironment (Review).Oncology reports · 2026Review
- A bibliometric analysis of artificial intelligence in ovarian cancer research from 2006 to 2025.Discover oncology · 2026Article
- VAV2-associated ncRNA network in the focal adhesion pathway is dysregulated in laryngeal squamous cell carcinoma.Discover oncology · 2026Article
- Investigation of CALML6 expression and its clinical relevance across pan-cancer.Discover oncology · 2026Article
- Comprehensive bioinformatics analysis of EXOSC family genes in lung adenocarcinoma.Discover oncology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Bisphenol A (BPA) is an endocrine-disrupting chemical that may contribute to cancer development. However, its role in lung adenocarcinoma (LUAD) remains poorly understood. This study aimed to investigate how BPA affects LUAD development by examining key genes involved in tumor progression and the immune microenvironment. Methods: Network toxicology, molecular docking, and clinical data analyses were performed to identify potential molecular targets of BPA in LUAD. Common genes between BPA targets and LUAD biomarkers were screened, and their biological significance was evaluated through survival analysis, immune infiltration assessment, and protein-ligand interaction studies. Results: A total of 218 overlapping genes were identified between BPA targets and LUAD biomarkers, including BUB1, BUB1B, CCNA2, CDK1, and UBE2C. These genes were strongly associated with LUAD progression, poor survival outcomes, and enhanced immune cell infiltration. Molecular docking revealed strong binding affinities between BPA and these proteins, suggesting potential disruption of their normal biological functions. Conclusion: This study provides valuable insights into the potential risks of BPA exposure in LUAD. The identified key genes and pathways may serve as potential biomarkers and therapeutic targets, offering new directions for future research and public health strategies.
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