Evidence map›Paper›PMID 41181120›Full record

ArticleFrontiers in immunology2025

Hyaluronic acid synthase 2 dysfunction exacerbates elastase-induced neutrophilic airway inflammation and emphysema in mice.

Kengo Nishino, Takumi Kiwamoto, Masashi Matsuyama, Zhenting Wei, Sosuke Matsumura, Kenya Kuramoto, Yuki Yabuuchi, Kai Yazaki, Kazufumi Yoshida, Yosuke Matsuno and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kengo NishinoDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Takumi KiwamotoDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Masashi MatsuyamaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Zhenting WeiDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Sosuke MatsumuraDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Kenya KuramotoDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Yuki YabuuchiDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Kai YazakiDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Kazufumi YoshidaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Yosuke MatsunoDepartment of Pulmonary Medicine, Nikko Memorial Hospital, Hitachi, Japan.
Yuko MorishimaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Nobuyuki HizawaDepartment of Pulmonary Medicine, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disorder primarily caused by prolonged exposure to harmful substances, such as cigarette smoke. Hyaluronic acid synthase 2 (HAS2) synthesizes high-molecular-weight hyaluronic acid (HMW-HA), which has anti-inflammatory properties. Previous studies have revealed that HAS2 dysfunction may exacerbate COPD. However, the specific impact of HAS2 on pulmonary emphysema progression remains unclear. Therefore, this study examined whether HAS2 dysfunction worsens airway inflammation and emphysema in a mouse COPD model.

Indexed as

Hyaluronan SynthasesNeutrophilsPancreatic ElastasePneumoniaPulmonary Disease, Chronic ObstructivePulmonary EmphysemaAnimalsDisease Models, AnimalHyaluronic AcidLungMaleMiceMice, Inbred C57BLMice, KnockoutHas2 protein, mouseHyaluronan SynthasesHyaluronic AcidPancreatic Elastasechronic obstructive pulmonary diseaseemphysemaG-CSFHAS2neutrophilTGF-β1

Identifiers

PMID41181120
PMCPMC12577564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.